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Invitrogen
AKR1B1 Polyclonal Antibody
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FIGURE: 1 / 1
AKR1B1 Antibody (PA5-89544) in WB
Western blot analysis of AKR1B1 in extracts of various cell lines. Samples were incubated with AKR1B1 Polyclonal antibody (Product # PA5-89544) using a dilution of 1:1,000, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST.
Product Details
PA5-89544
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 1-316 of human AKR1B1 (NP_0016191)
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
0.14 mg/mL
Amount
14 µg
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: MASRLLLNNG AKMPILGLGT WKSPPGQVTE AVKVAIDVGY RHIDCAHVYQ NENEVGVAIQ EKLREQVVKR EELFIVSKLW CTYHEKGLVK GACQKTLSDL KLDYLDLYLI HWPTGFKPGK EFFPLDESGN VVPSDTNILD TWAAMEELVD EGLVKAIGIS NFNHLQVEMI LNKPGLKYKP AVNQIECHPY LTQEKLIQYC QSKGIVVTAY SPLGSPDRPW AKPEDPSLLE DPRIKAIAAK HNKTTAQVLI RFPMQRNLVV IPKSVTPERI AENFKVFDFE LSSQDMTTLL SYNRNWRVCA LLSCTSHKDY PFHEEF; Positive Samples: HeLa, Jurkat, 293T, A-375, HepG2, Mouse heart; Cellular Location: Cytoplasm
Target Information
Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols with a broad range of catalytic efficiencies.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: AKR1B1; Aldehyde reductase; aldehyde reductase 1; aldo-keto reductase family 1; Aldo-keto reductase family 1 member B1; Aldo-keto reductase family 1 member B3; aldo-keto reductase family 1, member B1 (aldose reductase); Aldose reductase; aldose reductase (EC 1.1.1.21); AR; Lii5-2 CTCL tumor antigen; low Km aldose reductase; member B1 (aldose reductase); unnamed protein product
Gene Aliases: ADR; Ahr-1; Ahr1; AKR1B1; Akr1b3; Aldor1; ALDR1; ALR2; AR
UniProt ID: (Human) P15121, (Mouse) P45376
Entrez Gene ID: (Human) 231, (Mouse) 11677
retinal dehydrogenase activity
alditol:NADP+ 1-oxidoreductase activity
protein binding
electron carrier activity
oxidoreductase activity
prostaglandin H2 endoperoxidase reductase activity
glyceraldehyde oxidoreductase activity
allyl-alcohol dehydrogenase activity
L-glucuronate reductase activity
glycerol dehydrogenase (NADP+) activity
NADP-retinol dehydrogenase activity
oxidoreductase
reductase
metabolite interconversion enzyme
retinoid metabolic process
epithelial cell maturation
renal water homeostasis
carbohydrate metabolic process
lipid metabolic process
prostaglandin metabolic process
C21-steroid hormone biosynthetic process
regulation of urine volume
retinol metabolic process
negative regulation of apoptotic process
daunorubicin metabolic process
doxorubicin metabolic process
fructose biosynthetic process
cellular hyperosmotic salinity response
metanephric collecting duct development
tissue homeostasis
monosaccharide metabolic process
sorbitol biosynthetic process
response to water deprivation
response to organic substance
naphthalene metabolic process
stress-activated protein kinase signaling cascade
norepinephrine metabolic process
positive regulation of JAK-STAT cascade
positive regulation of smooth muscle cell proliferation
oxidation-reduction process
cellular response to hydrogen peroxide
inner medullary collecting duct development
cellular response to methylglyoxal
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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