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Invitrogen
Phospho-HCLS1 (Tyr378) Polyclonal Antibody
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Product Details
PA5-99149
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human HCLS1(Accession P14317), corresponding to amino acid residues around phosphorylated Tyr378.
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
sequential chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Antibody detects endogenous levels of HCLS1 only when phosphorylated at Tyrosine 378.
Target Information
Substrate of the antigen receptor-coupled tyrosine kinase. Plays a role in antigen receptor signaling for both clonal expansion and deletion in lymphoid cells. May also be involved in the regulation of gene expression. [UniProt]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: HCLS1; Hematopoietic cell-specific LYN substrate 1; Hematopoietic lineage cell-specific protein; LckBP1; p75; unnamed protein product
Gene Aliases: CTTNL; HCLS1; HS1; lckBP1; p75
UniProt ID: (Human) P14317
Entrez Gene ID: (Human) 3059
negative regulation of transcription from RNA polymerase II promoter
regulation of transcription, DNA-templated
actin filament organization
signal transduction
positive regulation of cell proliferation
response to hormone
erythrocyte differentiation
regulation of actin filament polymerization
positive regulation of granulocyte differentiation
intracellular signal transduction
granulocyte colony-stimulating factor signaling pathway
positive regulation of protein import into nucleus
positive regulation of macrophage differentiation
positive regulation of transcription from RNA polymerase II promoter
nuclear transport
positive regulation of protein kinase B signaling
cellular response to cytokine stimulus
negative regulation of leukocyte apoptotic process
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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