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Invitrogen
Cyclin G1 Polyclonal Antibody
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FIGURE: 1 / 3
Cyclin G1 Antibody (PA5-99163) in ICC/IF
Immunocytochemistry analysis of Cyclin G1 in A549 cells. The samples were fixed with PFA and permeabilized in 0.1% Triton X-100, then blocked in 10% serum for 45 minutes at 25°C. Samples were incubated with Cyclin G1 polyclonal antibody (Product # PA5-99163) and mouse anti-beta tubulin antibody for 1 hour at 37°C. An AlexaFluor594 conjugated goat anti-rabbit IgG(H+L) (Red) and an AlexaFluor488 conjugated go... View More
Product Details
PA5-99163
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human CCNG1(Accession P51959), corresponding to amino acid residues R174-I224.
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Antibody detects endogenous levels of total Cyclin G.
Target Information
Cyclins are the regulatory subunits of Cdc2 p34 and related cyclin-dependent kinases (Cdks) which play critical roles in the control of cell cycle progression. The catalytic subunit for cyclin A and B is Cdc2 p34 kinase. The Cdc2- cyclin B complex controls the G2 to M transition whereas Cdc2-cyclin A regulates S phase progression. The G1 to S transition, however, appears to be controlled by the G1 cyclins. Cyclin D1 accumulates during G1 and associates with Cdk2, Cdk4 and Cdk5. Cyclin E and Cdk2 interact during the G1 to S transition. Cyclin G contains a typical N terminal cyclin box and a carboxy terminal domain sequence homologous to the tyrosine phosphorylation site of the epidermal growth factor receptor. Cyclin G expression is induced within 3 hours after growth stimulation and remains elevated with no apparent cell cycle dependency. Cyclin G2 shares 53% amino acid sequence identity with cyclin G1. Peak expression of cyclin G2 is seen in late S phase, as opposed to cyclin G1 expression, which is constitutive.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Cyclin-G; Cyclin-G1; unnamed protein product
Gene Aliases: AI314029; CCNG; CCNG1; CYCG; CYCG1
UniProt ID: (Human) P51959, (Mouse) P51945, (Rat) P39950
Entrez Gene ID: (Human) 900, (Mouse) 12450, (Rat) 25405
regulation of cyclin-dependent protein serine/threonine kinase activity
G1/S transition of mitotic cell cycle
cell division
syncytium formation
cell cycle
mitotic nuclear division
mitotic G2 DNA damage checkpoint
negative regulation of apoptotic process
regulation of cell cycle
brain development
response to organonitrogen compound
cell growth
Disclaimer
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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