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OriGene
CD40 Monoclonal Antibody (OTI2C7), TrueMAB™
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FIGURE: 1 / 1
CD40 Antibody (TA812678) in Flow
Flow cytometric analysis of living 293T cells transfected with CD40 overexpression plasmid (RC201977), Red)/empty vector (PS100001, Blue) using anti-CD40 antibody (TA812678). Cells incubated with a non-specific antibody (Green) were used as isotype control (1:100).
Product Details
TA812678
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
OTI2C7
Immunogen
Human recombinant protein fragment corresponding to amino acids 21-193+Mouse Fc of human CD40 (NP_001241) produced in 293E cell.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Protein A/G
Storage buffer
PBS with 1% BSA, 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
CD40 is a single-chain glycoprotein and a member of the tumor necrosis factor receptor (TNFR) family, exhibiting significant homology to the Hodgkin's disease-associated antigen, CD30. It is expressed by B lymphocytes, follicular dendritic cells, thymic epithelium, and a subset of peripheral T cells, as well as some epithelial cells, carcinomas, and lymphoid dendritic cells. Notably, CD40 is present on all B cells except plasma cells. CD40 plays a crucial role in regulating B cell development and maturation, inducing immunoglobulin isotype-switching, and protecting B cells from surface Ig-induced apoptosis when combined with other signals such as IL-4. It promotes proliferation and is essential for T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. The interaction between CD40 and its ligand CD154 (gp39) on T cells is vital for T-B cell crosstalk, costimulation, and immune regulation. Adaptor protein TNFR2 interacts with CD40, mediating signal transduction, while the AT-hook transcription factor AKNA is reported to regulate CD40 expression, which may be important for homotypic cell interactions. Additionally, the interaction between CD40 and its ligand is necessary for amyloid-beta-induced microglial activation, suggesting a role in the early pathogenesis of Alzheimer's disease. Two alternatively spliced transcript variants encoding distinct isoforms of CD40 have been identified. Diseases associated with CD40 dysfunction include Type 3 Hyper-IgM immunodeficiency and CD40 ligand deficiency, highlighting its importance in immune and inflammatory responses.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: B cell surface antigen CD40; B cell-associated molecule; B-cell surface antigen CD40; Bp50; CD antigen CD40; CD40; CD40 molecule, TNF receptor superfamily member 5; CD40L receptor; CDw40; Immunoglobulin M; ImmunoglobulinM; MGC9013; sCD40; soluble CD40; Tumor necrosis factor receptor superfamily member 5
Gene Aliases: Bp50; CD40; CDW40; p50; TNFRSF5
UniProt ID: (Human) P25942
Entrez Gene ID: (Human) 958
immune system process
regulation of immunoglobulin production
immune response-regulating cell surface receptor signaling pathway
cellular calcium ion homeostasis
defense response
inflammatory response
JAK-STAT cascade
response to bacterium
regulation of gene expression
positive regulation of macromolecule biosynthetic process
B cell mediated immunity
CD40 signaling pathway
platelet activation
positive regulation of B cell proliferation
response to nutrient levels
positive regulation of interleukin-12 production
response to cobalamin
response to interferon-gamma
cellular response to erythropoietin
B cell proliferation
B cell activation
defense response to protozoan
positive regulation of I-kappaB kinase/NF-kappaB signaling
positive regulation of MAPK cascade
protein kinase B signaling
positive regulation of blood vessel endothelial cell migration
positive regulation of angiogenesis
positive regulation of nucleobase-containing compound metabolic process
positive regulation of transcription from RNA polymerase II promoter
positive regulation of isotype switching to IgG isotypes
regulation of immune response
positive regulation of developmental process
positive regulation of multicellular organismal process
defense response to virus
protein-containing complex assembly
cellular response to lipopolysaccharide
cellular response to mechanical stimulus
cellular response to interleukin-1
cellular response to tumor necrosis factor
positive regulation of protein kinase C signaling
response to peptide
positive regulation of interleukin-4-mediated signaling pathway
positive regulation of endothelial cell apoptotic process
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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