Dexamethasone, 96%, Thermo Scientific Chemicals

Name: Dexamethasone, 96%, Thermo Scientific Chemicals
SKU: 230302500

Dexamethasone, CAS# 50-02-2, is a synthetic adrenal corticosteroid that shows potent anti-inflammatory activity.

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Catalog Number	Quantity	Packaging
230302500	250mg	Glass bottle
230300010	1g	Glass bottle
230300050	5g	Glass bottle

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Catalog number 230302500

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Quantity:

250mg

Packaging:

Glass bottle

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Chemical Identifiers

CAS50-02-2

IUPAC Name(1R,2R,3aS,3bS,9aS,9bR,10S,11aS)-9b-fluoro-1,10-dihydroxy-1-(2-hydroxyacetyl)-2,9a,11a-trimethyl-1H,2H,3H,3aH,3bH,4H,5H,7H,9aH,9bH,10H,11H,11aH-cyclopenta[a]phenanthren-7-one

Molecular FormulaC22H29FO5

InChI KeyUREBDLICKHMUKA-CXSFZGCWSA-N

SMILESC[C@@H]1C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@]4(C)[C@@]3(F)[C@@H](O)C[C@]2(C)[C@@]1(O)C(=O)CO

Specifications

Specification Sheet

Appearance (Form)Crystalline powder

Infrared spectrumConforms

UV spectrophotometry>=95 % (On dried substance)

Specific optical rotation+86° to +92° (20°C, 589 nm) (c=1, ethanol)

Specific optical rotationOn dried substance

This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. Some documentation and label information may refer to the legacy brand. The original Acros Organics product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

General Information

• Dexamethasone is a synthetic adrenal glucocorticoid that modulates carbohydrate metabolism, inhibits adrenocorticotropic hormone secretion, and has pronounced anti-inflammatory activity
• Dexamethasone can bind to specific nuclear steroid receptors, inhibiting pro-inflammatory signals, promoting anti-inflammatory signals, and interfering with NF-kB activation and apoptotic pathways

Applications

• It can be used to study apoptosis, cell signaling pathways, and gene expression
• This compound also shows adrenergic, antiemetic, and antineoplastic activities
• It has been used as an important regulator of cellular proliferation and differentiation in vitro human cell cultures
• Dexamethasone has been applied in culture media to promote the differentiation of adipose-derived stem cells into osteogenic tissue
• It is used in in vitro stimulation of primary normal human bronchial epithelial cells (NHBE) and airway smooth muscle (ASM)
• This compound is used for its ability to regulate T cell survival, growth, and differentiation.
• It can also inhibit the induction of nitric oxide synthase.

RUO – Research Use Only

Literature References
McCulloch, C.; Tenenbaum, H. Dexamethasone induces proliferation and terminal differentiation of osteogenic cells in tissue culture. Anat Rec. 1986, 215, (4), 397-402.

Pasarica, M.; Mashtalir, N.; McAllister, E. et al.Adipogenic human adenovirus Ad-36 induces commitment, differentiation, and lipid accumulation in human adipose-derived stem cells. Stem Cells. 2008, 26, (4), 969-978.

Han, L.; Wang, Z.; Lu, X.; Dong, L.; Xie, C.; Wang, K.; Chen, X.; Ding, Y.; Weng, L. Mussel-inspired adhesive and transferable free-standing films by self-assembling dexamethasone encapsulated BSA nanoparticles and vancomycin immobilized oxidized alginate. Colloids Surf., B 2015, 126, 452-458.

Khataee, A.; Hasanzadeh, A.; Lotfi, R.; Pourata, R.; Joo, S. W. Determination of dexamethasone by flow-injection chemiluminescence method using capped CdS quantum dots. Spectrochim. Acta, Part A 2015, 150 (5), 63-71.