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Thermo Scientific Chemicals
Staurosporine, 98%
Staurosporine (staurosporin, CAS # 62996-74-1) is a bacterial alkyloid isolated from Streptomyces staurosporeus.
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| Catalog Number | Quantity |
|---|---|
| 328530010 | 1mg |
| 328532500 | 250μg |
Chemical Identifiers
CAS62996-74-1
IUPAC Name(2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-29-oxa-1,7,17-triazaoctacyclo[12.12.2.1²,⁶.0⁷,²⁸.0⁸,¹³.0¹⁵,¹⁹.0²⁰,²⁷.0²¹,²⁶]nonacosa-8,10,12,14(28),15(19),20(27),21(26),22,24-nonaen-16-one
Molecular FormulaC28H26N4O3
InChI KeyHKSZLNNOFSGOKW-FYTWVXJKSA-N
SMILESCN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)N1C3=C(C=CC=C3)C3=C1C1=C(C4=CC=CC=C4N21)C1=C3CNC1=O
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Specifications
Specification Sheet
Specification SheetHPLC>=97.5 %
Appearance (Color)White to light yellow to light beige
Appearance (Form)Powder
This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. Some documentation and label information may refer to the legacy brand. The original Acros Organics product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.
General Description
• Staurosporine is an indolocarbazole alkaloid capable of permeating cell membranes
• Staurosporine has anti-cancer properties that can induce apoptosis
• Staurosporine is a broad inhibitor of protein kinases, preventing growth and division cycles
Application
• Staurosporine is used for research on acute myeloid leukemia
• It is suitable for research applications including cell culture, in vivo studies, and biochemistry
RUO – Research Use Only
Literature References
Tang WL, Chen WC, Roy A, Undzys E, Li SD. A Simple and Improved Active Loading Method to Efficiently Encapsulate Staurosporine into Lipid-Based Nanoparticles for Enhanced Therapy of Multidrug Resistant Cancer. Pharm Res. 2016 May;33(5):1104-14. doi: 10.1007/s11095-015-1854-4. Epub 2016 Jan 12. PMID: 26758590.
Olguín-Albuerne M, Ramos-Pittol JM, Coyoy A, Martínez-Briseño CP, Domínguez G, Morán J. Peroxynitrite is Involved in the Apoptotic Death of Cultured Cerebellar Granule Neurons Induced by Staurosporine, but not by Potassium Deprivation. Neurochem Res. 2016 Feb;41(1-2):316-27. doi: 10.1007/s11064-015-1805-9. Epub 2015 Dec 23. PMID: 26700430.