Clindamycin hydrochloride, 97%

Clindamycin hydrochloride, CAS # 21462-39-5, is a lincosamide antibiotic. | CAS: 21462-39-5 | C18H34Cl2N2O5S | 461.439 g/mol

Catalog Number	Quantity
443510100	10 mg

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Catalog number 443510100

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10 mg

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Chemical Identifiers

CAS21462-39-5

IUPAC Namehydrogen (2S,4R)-N-{2-chloro-1-[(2R,3R,4S,5R,6R)-3,4,5-trihydroxy-6-(methylsulfanyl)oxan-2-yl]propyl}-1-methyl-4-propylpyrrolidine-2-carboxamide chloride

Molecular FormulaC18H34Cl2N2O5S

InChI KeyAUODDLQVRAJAJM-GQYOKNPUSA-N

SMILES[H+].[Cl-].CCC[C@@H]1C[C@H](N(C)C1)C(=O)NC(C(C)Cl)[C@H]1O[C@H](SC)[C@H](O)[C@@H](O)[C@H]1O

Specifications

Appearance (Form)Crystalline powder

Water=<6 %

HPLC>=96.0 %

Infrared spectrumConforms

Appearance (Color)White to almost white

This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. Some documentation and label information may refer to the legacy brand. The original Acros Organics product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

General Description

Clindamycin is a lincosamide antibiotic derived from lincomycin that has antibiotic activity against aerobic gram-positive cocci, and parasitic protozoa
Clindamycin reversibly binds to the 50s bacterial ribosomal subunit, thus inhibiting protein synthesis

Applications

Clindamycin has been used to enhance bacterial colonization in research mice during the study of commensal gut microbiota
Clindamycin has been used to study biofilm-mediated antibiotic resistance in an in vitro model of G. vaginalis
Clindamycin was used as a selection agent to isolate, enumerate, and identify Lactobacillus spp. from probiotic dairy products

RUO – Research Use Only

General References:

Spížek, J.; Řezanka, T. Lincosamides: Chemical structure, biosynthesis, mechanism of action, resistance, and applications. Biochem Pharmacol. 2017, 133:20-28.
Patterson, L.; Allen, J.; Posey, I.; Shaw, J.J.P.; Costa-Pinheiro P, Walker SJ, Gademsey A, Wu X, Wu S, Zachos NC, Fox TE, Sears CL, Kester M. Glucosylceramide production maintains colon integrity in response to Bacteroides fragilis toxin-induced colon epithelial cell signaling. FASEB J. 2020, 34(12), 15922-15945.
Farahmand, N.; Ouoba, L.I.I.; Naghizadeh Raeisi, S.; Sutherland, J.; Ghoddusi, H.B. Probiotic Lactobacilli in Fermented Dairy Products: Selective Detection, Enumeration and Identification Scheme. Microorganisms. 2021, 9(8), 1600.