Melphalan, 94%

Melphalan, CAS # 148-82-3, belongs to the class of nitrogen mustards with anti-neoplastic activity. | CAS: 148-82-3 | C₁₃H₁₈Cl₂N₂O₂ | 305.2 g/mol

Catalog Number	Quantity
458650050	5 g

Catalog number 458650050

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Chemical Identifiers

CAS148-82-3

IUPAC Name2-amino-3-{4-[bis(2-chloroethyl)amino]phenyl}propanoic acid

Molecular FormulaC13H18Cl2N2O2

InChI KeySGDBTWWWUNNDEQ-UHFFFAOYNA-N

SMILESNC(CC1=CC=C(C=C1)N(CCCl)CCCl)C(O)=O

Specifications

Appearance (Form)Powder

Infrared spectrumConforms

Water=<5 %

HPLC>=93 %

Appearance (Color)White to light yellow

This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. Some documentation and label information may refer to the legacy brand. The original Acros Organics product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

General Description

Melphalan is a phenylalanine derivative of nitrogen mustard with antineoplastic activity with the capacity to alkylate nucleic acids
Melphalan alkylates DNA at the N-7 position of guanine and induces DNA interstrand cross-linkages, resulting in the inhibition of DNA/RNA synthesis, inducing cytotoxicity against both dividing and non-dividing tumor cells

Applications

Melphalan has been used in in vitro experiments to treat multiple myeloma in cell lines and breast cancer cell lines
In in vivo experiments, using rats, it shows a potent therapeutic effect in cases of sarcomatous pulmonary metastases

RUO – Research Use Only

General References:

Betcher, D.; Burnham, N. Melphalan. J Pediatr Oncol Nurs. 1990, 7 (1), 35-36.
Nawata, S.; Abecasis, N.; Ross, H.M.; Abolhoda, A.; Cheng, H.; Sachar, K.S.; Burt, M.E. Isolated lung perfusion with melphalan for the treatment of metastatic pulmonary sarcoma. J Thorac Cardiovasc Surg. 1996, 112, (6), 1542-1547.
Stühmer, T.; Arts, J.; Chatterjee, M.; Borawski,, J, Wolff A, King P, Einsele H, Leo E, Bargou RC. Preclinical anti-myeloma activity of the novel HDAC-inhibitor JNJ-26481585. Br J Haematol. 2010, 149, (4), 529-536.
Bauer, G.B.; Povirk, L.F. Specificity and kinetics of interstrand and intrastrand bifunctional alkylation by nitrogen mustards at a G-G-C sequence. Nucleic Acids Res. 1997, 25, (6), 1211-1218.