Fluorometholone, 97%, Thermo Scientific Chemicals

Fluorometholone, CAS # 426-13-1, is a glucocorticoid with anti-inflammatory properties.

Catalog Number	Quantity
460200010	1g

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Catalog number 460200010

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Chemical Identifiers

CAS426-13-1

IUPAC Name(1R,3aS,3bS,5S,9aS,9bR,10S,11aS)-1-acetyl-9b-fluoro-1,10-dihydroxy-5,9a,11a-trimethyl-1H,2H,3H,3aH,3bH,4H,5H,7H,9aH,9bH,10H,11H,11aH-cyclopenta[a]phenanthren-7-one

Molecular FormulaC22H29FO4

InChI KeyFAOZLTXFLGPHNG-KNAQIMQKSA-N

SMILESC[C@H]1C[C@H]2[C@@H]3CC[C@](O)(C(C)=O)[C@@]3(C)C[C@H](O)[C@]2(F)[C@@]2(C)C=CC(=O)C=C12

Specifications

Loss on drying=<1 %

Appearance (Color)White to off-white

Infrared spectrumConforms

Solubility(2.5 % in pyridine) clear colorless to light yellow

Appearance (Form)Powder

This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. Some documentation and label information may refer to the legacy brand. The original Acros Organics product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

General Description

• Fluorometholone is a synthetic glucocorticoid

• It has anti-inflammatory properties

Applications

• Fluorometholone interacts with cytoplasmic glucocorticoid receptors resulting in activation of these receptors, which mediates gene expression

RUO – Research Use Only

Literature References

Hofmann, A.F. Detoxification of lithocholic acid, a toxic bile acid: relevance to drug hepatotoxicity. Drug Metab Rev. 2004, 36 (3-4), 703-22.

Diao, H., et al. Comparison of Tacrolimus, Fluorometholone, and Saline in Mild-to-Moderate Contact Lens-Induced Papillary Conjunctivitis. Adv Therapy. 2012, 29, 645–653.