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4,4'-Diaminodiphenyl sulfone, 98%
4,4'-Diaminodiphenyl sulfone, 98%
4,4'-Diaminodiphenyl sulfone, 98%
Thermo Scientific Chemicals

4,4'-Diaminodiphenyl sulfone, 98%

CAS: 80-08-0 | C12H12N2O2S | 248.3 g/mol
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Catalog number A18976.36
also known as A18976-36
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Quantity:
500 g
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Chemical Identifiers
CAS80-08-0
IUPAC Name4-(4-aminobenzenesulfonyl)aniline
Molecular FormulaC12H12N2O2S
InChI KeyMQJKPEGWNLWLTK-UHFFFAOYSA-N
SMILESNC1=CC=C(C=C1)S(=O)(=O)C1=CC=C(N)C=C1
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SpecificationsSpecification SheetSpecification Sheet
Appearance (Color)White to pale cream
FormPowder
Assay (HPLC)≥97.5%
Identification (FTIR)Conforms (non-U.S. specification)
Melting Point (clear melt)175.0-181.0°C (non-U.S. specification)
It is active against a wide range of bacteria, but is mainly employed for its actions against Mycobacterium leprae, being used as part of multidrug regimens in the treatment of all forms of leprosy. It is a second-line medication for the treatment and prevention of Pneumocystis pneumonia and for the prevention of toxoplasmosis in those who have poor immune function. Additionally, it has been used for acne as well as other skin conditions. Moreover it is employed as an anti-inflammatory drug, anti-infective drug, a leprostatic drug and an antimalarial drug.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Solubility
Insoluble in water. Solubility in hot methanol is almost transparent. Soluble in DMSO, ethanol and acetone.

Notes
Store away from oxidizing agents. Keep the container tightly closed and place it in a cool, dry and well ventilated condition.
RUO – Research Use Only

General References:

  1. Patel AP, Patil AS. Dapsone for immune thrombocytopenic purpura in children and adults.Therapeutic drug monitoring.2014,36(2), 261-263.
  2. B.L. Maloff, et al. Dapsone inhibits LTB4 binding and bioresponse at the cellular and physiologic levels.Eur. J. Pharmacol.1988158(1-2), 85-89.