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Thermo Scientific Chemicals
Ethyl p-toluenesulfonate, 98%
CAS: 80-40-0 | C9H12O3S | 200.252 g/mol
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Catalog number B24658.30
also known as B24658-30
Price (JPY)
-
Quantity:
250 g
Chemical Identifiers
CAS80-40-0
IUPAC Nameethyl 4-methylbenzene-1-sulfonate
Molecular FormulaC9H12O3S
InChI KeyVRZVPALEJCLXPR-UHFFFAOYSA-N
SMILESCCOS(=O)(=O)C1=CC=C(C)C=C1
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Specifications
Specification Sheet
Specification SheetAppearance (Color)White to yellow to brown
FormFused solid or liquid as melt
Assay (GC)≥97.5%
Identification (FTIR)Conforms
Melting Point (clear melt)29.0-35.0°C
Ethyl p-toluenesulfonate was used to develop an extraction method for methyl and ethyl esters of various sulfonic acids in active pharmaceutical ingredients using solid-phase micro extraction coupled to GC/MS in the selected ion monitoring mode. It was used in a study to develop a fast and accurate method for determination of residues of some common alkylating agents employed in drug synthesis by in situ derivatization-headspace-gas chromatography-mass spectrometry.
This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.
Applications
Ethyl p-toluenesulfonate was used to develop an extraction method for methyl and ethyl esters of various sulfonic acids in active pharmaceutical ingredients using solid-phase micro extraction coupled to GC/MS in the selected ion monitoring mode. It was used in a study to develop a fast and accurate method for determination of residues of some common alkylating agents employed in drug synthesis by in situ derivatization-headspace-gas chromatography-mass spectrometry.
Solubility
Insoluble in water.
Notes
Moisture sensitive. Store away from oxidizing agent.
Ethyl p-toluenesulfonate was used to develop an extraction method for methyl and ethyl esters of various sulfonic acids in active pharmaceutical ingredients using solid-phase micro extraction coupled to GC/MS in the selected ion monitoring mode. It was used in a study to develop a fast and accurate method for determination of residues of some common alkylating agents employed in drug synthesis by in situ derivatization-headspace-gas chromatography-mass spectrometry.
Solubility
Insoluble in water.
Notes
Moisture sensitive. Store away from oxidizing agent.
RUO – Research Use Only
General References:
- Roberto Alzaga; Robert W Ryan; Karen Taylor-Worth; Andrew M Lipczynski; Roman Szucs; Pat Sandra. A generic approach for the determination of residues of alkylating agents in active pharmaceutical ingredients by in situ derivatization-headspace-gas chromatography-mass spectrometry. Journal of Pharmaceutical and Biomedical Analysis. 2007, 45 (3), 472-479.
- Ivelisse Colón; Stephen M Richoll. Determination of methyl and ethyl esters of methanesulfonic, benzenesulfonic and p-toluenesulfonic acids in active pharmaceutical ingredients by solid-phase microextraction (SPME) coupled to GC/SIM-MS. Journal of Pharmaceutical and Biomedical Analysis. 2005, 39 (3-4), 477-485.