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Thermo Scientific Chemicals
6(5H)-Phenanthridinone, 96%
CAS: 1015-89-0 | C13H9NO | 195.221 g/mol
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Catalog number B25187.06
also known as B25187-06
Price (JPY)Request A Quote
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Quantity:
5 g
Chemical Identifiers
CAS1015-89-0
IUPAC Name5,6-dihydrophenanthridin-6-one
Molecular FormulaC13H9NO
InChI KeyRZFVLEJOHSLEFR-UHFFFAOYSA-N
SMILESO=C1NC2=CC=CC=C2C2=CC=CC=C12
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Specifications
Specification Sheet
Specification SheetAppearance (Color)Cream to pale brown
Assay (HPLC)≥95.0%
Melting Point (clear melt)288.0-298.0?C
FormPowder
6(5H)-Phenanthridinone is used as a probe into the role of PARP in cellular response to irradiation. Treatment of cells with 6(5H)-Phenanthridinone and various DNA-damaging agents showed a resistance to apoptosis. It acts as a reactant in the synthesis of 5,6-dihydrophenanthridine sulfonamides, oxidative coupling with diphenylacetylene, direct copper acetate-catalyzed N-cyclopropylation of cyclic amides. It is used as HIV-1 integrase inhibitor.
This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.
Applications
6(5H)-Phenanthridinone is used as a probe into the role of PARP in cellular response to irradiation. Treatment of cells with 6(5H)-Phenanthridinone and various DNA-damaging agents showed a resistance to apoptosis. It acts as a reactant in the synthesis of 5,6-dihydrophenanthridine sulfonamides, oxidative coupling with diphenylacetylene, direct copper acetate-catalyzed N-cyclopropylation of cyclic amides. It is used as HIV-1 integrase inhibitor.
Solubility
Soluble in DMSO (5 mg/ml). Insoluble in water.
Notes
Incompatible materials are oxidizing agents. Store in cool place. Keep container tightly closed in a dry and well-ventilated place.
6(5H)-Phenanthridinone is used as a probe into the role of PARP in cellular response to irradiation. Treatment of cells with 6(5H)-Phenanthridinone and various DNA-damaging agents showed a resistance to apoptosis. It acts as a reactant in the synthesis of 5,6-dihydrophenanthridine sulfonamides, oxidative coupling with diphenylacetylene, direct copper acetate-catalyzed N-cyclopropylation of cyclic amides. It is used as HIV-1 integrase inhibitor.
Solubility
Soluble in DMSO (5 mg/ml). Insoluble in water.
Notes
Incompatible materials are oxidizing agents. Store in cool place. Keep container tightly closed in a dry and well-ventilated place.
RUO – Research Use Only
General References:
- Guoyong Song; Dan Chen; Cheng-Ling Pan; Robert H Crabtree; Xingwei Li. Rh-catalyzed oxidative coupling between primary and secondary benzamides and alkynes: synthesis of polycyclic amides. Journal of Organic Chemistry.2010, 75, (21), 7487-7490.
- D Weltin; J Marchal; P Dufour; E Potworowski; D Oth; P Bischoff. Effect of 6(5H)-phenanthridinone, an inhibitor of poly(ADP-ribose) polymerase, on cultured tumor cells. Oncology Research.1994, 6, (9), 399-403.