DRAQ7™ Dye

Name: DRAQ7™ Dye
SKU: D15106

DRAQ7 Dye is a bright, easy-to-use fluorescent DNA dye used to exclude non-viable cells by flow cytometry. This dye hasRead more

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Catalog Number	Quantity
D15106	200 Assays
D15105	50 Assays

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Catalog number D15106

Price (JPY)

74,700

200 assays

Quantity:

200 Assays

DRAQ7 Dye is a bright, easy-to-use fluorescent DNA dye used to exclude non-viable cells by flow cytometry. This dye has excitation maxima at 599/644 nm and emission maxima at 678/697 nm.

• Stable at room temperature
• Rapid staining of dead cells without wash steps
• No UV excitation and no emission spectral overlap with PE

DRAQ7 Dye is a membrane-impermeable dye that rapidly stains the double-stranded DNA (dsDNA) of dead or permeabilized cells. The dye can be excited by wavelengths from 488 to 647 nm, though it is optimally excited by red laser lines. Its emission maxima is at 697 nm when intercalated with dsDNA.

For Research Use Only. Not for use in diagnostic procedures.

Specifications

Quantity200 Assays

Product TypeDye

Unit Size200 assays

Contents & Storage

Store at room temperature.

Citations & References (4)

Citations & References

Abstract

Real-time cell viability assays using a new anthracycline derivative DRAQ7®.

Authors:Akagi J, Kordon M, Zhao H, Matuszek A, Dobrucki J, Errington R, Smith PJ, Takeda K, Darzynkiewicz Z, Wlodkowic D,

Journal:Cytometry A

PubMed ID:23165976

'The exclusion of charged fluorescent dyes by intact cells has become a well-established assay for determining viability of cells. In search for a noninvasive fluorescent probe capable of long-term monitoring of cell death in real-time, we evaluated a new anthracycline derivative DRAQ7. The novel probe does not penetrate the plasma ... More

BET Bromodomain Inhibitor iBET151 Impedes Human ILC2 Activation and Prevents Experimental Allergic Lung Inflammation.

Authors:Kerscher B, Barlow JL, Rana BM, Jolin HE, Gogoi M, Bartholomew MA, Jhamb D, Pandey A, Tough DF, van Oosterhout AJM, McKenzie ANJ,

Journal:Front Immunol

PubMed ID:31024538

'Group 2 innate lymphoid cells (ILC2) increase in frequency in eczema and allergic asthma patients, and thus represent a new therapeutic target cell for type-2 immune-mediated disease. The bromodomain and extra-terminal (BET) protein family of epigenetic regulators are known to support the expression of cell cycle and pro-inflammatory genes during ... More

Lysosomotropic challenge of mast cells causes intra-granular reactive oxygen species production.

Authors:Paivandy A, Eriksson J, Melo FR, Sellin ME, Pejler G,

Journal:Cell Death Discov

PubMed ID:31123601

'Mast cells contribute to the pathology of allergic and other disorders. Strategies to interfere with harmful mast cell-related activities are therefore warranted. Previously we established a principle for inducing selective apoptosis of mast cells, by the use of lysosomotropic agents that cause secretory granule permeabilization, leading to production of reactive ... More

Cytokine-induced translocation of GRP78 to the plasma membrane triggers a pro-apoptotic feedback loop in pancreatic beta cells.

Authors:Vig S, Buitinga M, Rondas D, Crèvecoeur I, van Zandvoort M, Waelkens E, Eizirik DL, Gysemans C, Baatsen P, Mathieu C, Overbergh L,

Journal:Cell Death Dis

PubMed ID:30952835

The 78-kDa glucose-regulated protein (GRP78) is an ubiquitously expressed endoplasmic reticulum chaperone, with a central role in maintaining protein homeostasis. Recently, an alternative role for GRP78 under stress conditions has been proposed, with stress-induced extracellular secretion and translocation of GRP78 to the cell surface where it acts as a multifunctional ... More