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Thermo Scientific Chemicals
3-Acetylbenzenesulfonyl chloride, 97%
CAS: 73035-16-2 | C8H7ClO3S | 218.651 g/mol
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Chemical Identifiers
CAS73035-16-2
IUPAC Name3-acetylbenzene-1-sulfonyl chloride
Molecular FormulaC8H7ClO3S
InChI KeyCGMBNEIGZOCPPP-UHFFFAOYSA-N
SMILESCC(=O)C1=CC(=CC=C1)S(Cl)(=O)=O
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Specifications
Specification Sheet
Specification SheetAppearance (Color)White to pale cream to cream to brown
FormCrystals or powder or crystalline powder or fused solid
Assay (GC)≥96.0%
Melting Point (clear melt)38.0-48.0?C
Classical acetamidomalonate addition/decarboxylative hydrolysis as the key step for the generation of the amino acidic moiety starting from 4-ethylsulfonyl-α-bromoacetophenone prepared in two steps from commercially available 4-acetyl-benzenesulfonyl chloride. This then treated with sodium sulfite in basic aqueous conditions yielded the sodium sulfinate.
This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.
Applications
Classical acetamidomalonate addition/decarboxylative hydrolysis as the key step for the generation of the amino acidic moiety starting from 4-ethylsulfonyl-α-bromoacetophenone prepared in two steps from commercially available 4-acetyl-benzenesulfonyl chloride. This then treated with sodium sulfite in basic aqueous conditions yielded the sodium sulfinate.
Notes
Moisture Sensitive. Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Store away from strong oxidizing agents, water, moisture, bases.
Classical acetamidomalonate addition/decarboxylative hydrolysis as the key step for the generation of the amino acidic moiety starting from 4-ethylsulfonyl-α-bromoacetophenone prepared in two steps from commercially available 4-acetyl-benzenesulfonyl chloride. This then treated with sodium sulfite in basic aqueous conditions yielded the sodium sulfinate.
Notes
Moisture Sensitive. Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Store away from strong oxidizing agents, water, moisture, bases.
RUO – Research Use Only
Roberto Pellicciari Prof.1,; Rosa C. Rizzo Dr.,; Gabriele Costantino Prof.,; Maura Marinozzi Prof.,; Laura Amori Dr.,; Paolo Guidetti Dr.,; Hui-Qiu Wu Dr.,; Robert Schwarcz Dr. Modulators of the Kynurenine Pathway of Tryptophan Metabolism: Synthesis and Preliminary Biological Evaluation of (S)-4-(Ethylsulfonyl)benzoylalanine, a Potent and Selective Kynurenine Aminotransferase II (KAT II) Inhibitor. ChemMedChem. 2006, 1 (5), 528-531.