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![4,5,6,7-Tetrahydrobenzo[b]thiophene, 97%](/TFS-Assets/CCG/Chemical-Structures/chemical-structure-cas-13129-17-4.jpg-650.jpg)
![4,5,6,7-Tetrahydrobenzo[b]thiophene, 97%](/TFS-Assets/CCG/Chemical-Structures/chemical-structure-cas-13129-17-4.jpg-150.jpg)
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Thermo Scientific Chemicals
4,5,6,7-Tetrahydrobenzo[b]thiophene, 97%
CAS: 13129-17-4 | C8H10S | 138.228 g/mol
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Chemical Identifiers
CAS13129-17-4
IUPAC Name4,5,6,7-tetrahydro-1-benzothiophene
Molecular FormulaC8H10S
InChI KeyCBKDCOKSXCTDAA-UHFFFAOYSA-N
SMILESC1CCC2=C(C1)SC=C2
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Specifications
Specification Sheet
Specification SheetAppearance (Color)Clear colorless
FormLiquid
Assay (GC)≥96.0%
Refractive Index1.5560-1.5610 @ 20?C
It is an active pharmaceutical intermediate. Condensation of amino carboxyalkyl derivative of 4,5,6,7-tetrahydrobenzo[b]thiophene with salicylaldehyde yielded a potentially tridentate Schiff base (HSAT), which formed a series of copper(II) complexes. Reaction of ethyl 2-diazo-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylate 1 with 3-iminobutyronitrile 2 gave the hydrazone derivative.
This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.
Applications
It is an active pharmaceutical intermediate. Condensation of amino carboxyalkyl derivative of 4,5,6,7-tetrahydrobenzo[b]thiophene with salicylaldehyde yielded a potentially tridentate Schiff base (HSAT), which formed a series of copper(II) complexes. Reaction of ethyl 2-diazo-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylate 1 with 3-iminobutyronitrile 2 gave the hydrazone derivative.
Notes
Air sensitive. Store at room temperature. Keep container tightly closed in a dry and well-ventilated place.
It is an active pharmaceutical intermediate. Condensation of amino carboxyalkyl derivative of 4,5,6,7-tetrahydrobenzo[b]thiophene with salicylaldehyde yielded a potentially tridentate Schiff base (HSAT), which formed a series of copper(II) complexes. Reaction of ethyl 2-diazo-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylate 1 with 3-iminobutyronitrile 2 gave the hydrazone derivative.
Notes
Air sensitive. Store at room temperature. Keep container tightly closed in a dry and well-ventilated place.
RUO – Research Use Only
General References:
- V. Alagarsamy.;S. Meena.; K.V. Ramseshu.; V.R. Solomon.; K. Thirumurugan.; K. Dhanabal.; M. Murugan. Synthesis, analgesic, anti-inflammatory, ulcerogenic index and antibacterial activities of novel 2-methylthio-3-substituted-5,6,7,8-tetrahydrobenzo (b) thieno[2,3-d]pyrimidin-4(3H)-ones. Eur. J. Med. Chem. 2006, 41 (11),1293-1300.
- Rafat M. Mohareb,; Fatma M. Manhi. Reaction of ethyl 2-diazo-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylate with 3-iminobutyronitrile: synthesis of pyridazines, thiophenes, and their fused derivatives. Heteroatom Chemistry. 2000, 11 (6), 403-412,.