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Thermo Scientific Chemicals
1-Methylpiperidine, 99%
CAS: 626-67-5 | C6H14ClN | 135.64 g/mol
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Catalog number L03398.09
also known as L03398-09
Price (JPY)
-
Quantity:
10 g
Chemical Identifiers
CAS626-67-5
IUPAC Namehydrogen 1-methylpiperidine chloride
Molecular FormulaC6H14ClN
InChI KeyQDUXDCXILAPLAG-UHFFFAOYSA-N
SMILES[H+].[Cl-].CN1CCCCC1
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Specifications
Specification Sheet
Specification SheetAppearance (Color)Clear colorless to yellow
FormLiquid
Assay (GC)≥98.5%
Identification (FTIR)Conforms
1-Methylpiperidine is a reactant for sp3 C-H Bond activation with ruthenium(II) catalysts and C(3)-alkylation of cyclic amines, One-pot synthesis of Z-cinnamic acids. It is used in the synthesis of Unsymmetrical ureas, Antibacterial imidazolium, pyrrolidinium, and piperidinium salts, C1-C16 segment of goniodomin A via palladium-catalyzed organostannane thioester coupling.
This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.
Applications
1-Methylpiperidine is a reactant for sp3 C-H Bond activation with ruthenium(II) catalysts and C(3)-alkylation of cyclic amines, One-pot synthesis of Z-cinnamic acids. It is used in the synthesis of Unsymmetrical ureas, Antibacterial imidazolium, pyrrolidinium, and piperidinium salts, C1-C16 segment of goniodomin A via palladium-catalyzed organostannane thioester coupling.
Solubility
Fully miscible in water.
Notes
Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Incompatible with.acids, Acid chlorides, Acid anhydrides, Strong oxidizing agents, Carbon dioxide.
1-Methylpiperidine is a reactant for sp3 C-H Bond activation with ruthenium(II) catalysts and C(3)-alkylation of cyclic amines, One-pot synthesis of Z-cinnamic acids. It is used in the synthesis of Unsymmetrical ureas, Antibacterial imidazolium, pyrrolidinium, and piperidinium salts, C1-C16 segment of goniodomin A via palladium-catalyzed organostannane thioester coupling.
Solubility
Fully miscible in water.
Notes
Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Incompatible with.acids, Acid chlorides, Acid anhydrides, Strong oxidizing agents, Carbon dioxide.
RUO – Research Use Only
General References:
- Amina A. Fakhroo; Hassan S. Bazzi; Adel Mostafa; Lamis Shahada. Synthesis, spectroscopic and thermal structural investigations of the charge-transfer complexes formed in the reaction of 1-methylpiperidine with σ- and π-acceptors.Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy. Chem.2010, 75 134-141.
- G. Smith and G. A. Swan. The chemical effects of γ-radiation on organic systems. Part IV. The action of radiation on diethylamine, trimethylamine, benzylamine, phenethylamine, 1-methylpiperidine, N-methyldiethylamine, and t-butylamine.J. Chem. Soc. Chem.1962, 168 886-904.
- Use of this base in the mixed anhydride method of peptide coupling reduces cleavage of the mixed anhydride at the wrong site: J. Org. Chem., 48, 2939 (1983). See Appendix 6.