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Thermo Scientific Chemicals
4-Nitrophenyl-alpha-D-glucopyranoside, 98+%
CAS: 3767-28-0 | C12H15NO8 | 301.251 g/mol
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Chemical Identifiers
CAS3767-28-0
IUPAC Name(2R,3S,4S,5R,6R)-2-(hydroxymethyl)-6-(4-nitrophenoxy)oxane-3,4,5-triol
Molecular FormulaC12H15NO8
InChI KeyIFBHRQDFSNCLOZ-ZIQFBCGOSA-N
SMILESOC[C@H]1O[C@H](OC2=CC=C(C=C2)[N+]([O-])=O)[C@H](O)[C@@H](O)[C@@H]1O
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Specifications
Specification Sheet
Specification SheetFormCrystalline powder
CommentMaterial sourced in UK and US
Optical Rotation+216? ±6? (c=0.5 in Water, UK-sourced material)
Assay from Supplier's CofA≥98.0% (US-sourced material)
Identification (FTIR)Conforms (UK-sourced material)
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4-Nitrophenyl-α-D-glucopyranoside acts as a chromogenic substrate for alfa-D-glucosidase inhibitor. It is also used in the detection of glucansucrases and for yeast alfa-D-glucosidase. Further, it is a substrate for lysosomal alfa-glucosidase and maltase-glucoamylase.
This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.
Applications
4-Nitrophenyl-α-D-glucopyranoside acts as a chromogenic substrate for alfa-D-glucosidase inhibitor. It is also used in the detection of glucansucrases and for yeast alfa-D-glucosidase. Further, it is a substrate for lysosomal alfa-glucosidase and maltase-glucoamylase.
Solubility
Soluble in water, warm ethanol and methanol.
Notes
Store in a cool place. Keep the container tightly closed in a dry and well-ventilated place. Light sensitive. Incompatible with strong oxidizing agents.
4-Nitrophenyl-α-D-glucopyranoside acts as a chromogenic substrate for alfa-D-glucosidase inhibitor. It is also used in the detection of glucansucrases and for yeast alfa-D-glucosidase. Further, it is a substrate for lysosomal alfa-glucosidase and maltase-glucoamylase.
Solubility
Soluble in water, warm ethanol and methanol.
Notes
Store in a cool place. Keep the container tightly closed in a dry and well-ventilated place. Light sensitive. Incompatible with strong oxidizing agents.
RUO – Research Use Only
General References:
- Substrate for ɑ -glucosidase: Anal. Biochem., 113, 188 (1981).
- Zhao, D. G.; Zhou, A. Y.; Du, Z.; Zhang, Y.; Zhang, K.; Ma, Y. Y. Coumarins with alpha-glucosidase and alpha-amylase inhibitory activities from the flower of Edgeworthia gardneri. Fitoterapia 2015, 107, 122-127.
- Madeira, P. P.; Bessa, A.; Loureiro, J. A.; Álvares-Ribeiro, L.; Rodrigues, A. E.; Zaslavsky, B. Y. Cooperativity between various types of polar solute-solvent interactions in aqueous media. J. Chromatogr. A 2015, 1408, 108-117.