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Thermo Scientific Chemicals
(S)-(+)-5-(Hydroxymethyl)-2-pyrrolidinone, 98%
CAS: 17342-08-4 | C5H9NO2 | 115.132 g/mol
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Chemical Identifiers
CAS17342-08-4
IUPAC Name(5S)-5-(hydroxymethyl)pyrrolidin-2-one
Molecular FormulaC5H9NO2
InChI KeyHOBJEFOCIRXQKH-BYPYZUCNSA-N
SMILESOC[C@@H]1CCC(=O)N1
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Specifications
Specification Sheet
Specification SheetFormCrystals or powder or crystalline powder
Water Content (Karl Fischer Titration)≤1.5%
Appearance (Color)White to pale cream to pale brown
Optical Rotation30.5 ± 0.1? (C=2 in ethanol)
Assay (HPLC)≥97.5%
(S)-(+)-5-(Hydroxymethyl)-2-pyrrolidinone serves as a building block in the synthesis of (R)- and (S)-diaminovaleric acids1 and of 5-azasemicorrin bidentate nitrogen ligands for enantioselective catalysis.
This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.
Applications
(S)-(+)-5-(Hydroxymethyl)-2-pyrrolidinone serves as a building block in the synthesis of (R)- and (S)-diaminovaleric acids1 and of 5-azasemicorrin bidentate nitrogen ligands for enantioselective catalysis.
Solubility
Soluble in water.
Notes
Store in cool place. Keep container tightly closed in a dry and well-ventilated place.
(S)-(+)-5-(Hydroxymethyl)-2-pyrrolidinone serves as a building block in the synthesis of (R)- and (S)-diaminovaleric acids1 and of 5-azasemicorrin bidentate nitrogen ligands for enantioselective catalysis.
Solubility
Soluble in water.
Notes
Store in cool place. Keep container tightly closed in a dry and well-ventilated place.
RUO – Research Use Only
General References:
- Richard B. Silverman.; Mark A. Levy. Syntheses of (S)-5-substituted 4-aminopentanoic acids: a new class of .gamma.-aminobutyric acid transaminase inactivators. J. Org. Chem. 1980, 45 (5), 815-818.
- John K. Thottathil, Jerome L. Moniot, Richard H. Mueller, Michael K. Y. Wong, Thomas P. Kissick. Conversion of L-pyroglutamic acid to 4-alkyl-substituted L-prolines. The synthesis of trans-4-cyclohexyl-L-proline. J. Org. Chem. 1986, 51 (16), 3140-3143.