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引用資料與參考文獻 (5)
Thermo Scientific™
DMS (dimethyl suberimidate)
Thermo Scientific Pierce DMS is dimethyl suberimidate, a membrane-permeable crosslinker that contains an amine-reactive imidoester group at each end of深入閱讀
| 產品號碼 | Quantity |
|---|---|
| 20700 | 1 g |
產品號碼 20700
價格 (TWD)
6,320.00
Online offer
Ends: 31-Dec-2025
9,010.00您節省 2,690.00 (30%)
Each
Quantity:
1 g
價格 (TWD)
6,320.00
Online offer
Ends: 31-Dec-2025
9,010.00您節省 2,690.00 (30%)
Each
Thermo Scientific Pierce DMS is dimethyl suberimidate, a membrane-permeable crosslinker that contains an amine-reactive imidoester group at each end of an 8-atom spacer arm.
Features of dimethyl suberimidate:
• Reactive groups: imidoester (both ends)
• Reactive towards: amino groups (primary amines)
• Longest of three similar imidoester crosslinkers, which include DMA, DMP and DMS
• Water-soluble
• Imidoesters react with amines at alkaline pH values (pH 8-10) to form amidine bond
• Amidine bond retains net charge character of protein primary amine to which it reacts
• Reversible at high pH values
• Tool for study of quarternary structure of proteins
Product References
Crosslinker Application Guide -- search for recent literature references for this product
Related Products
DMA (dimethyl adipimidate)
DMP (dimethyl pimelimidate)
DTBP (Wang and Richard's Reagent)
Features of dimethyl suberimidate:
• Reactive groups: imidoester (both ends)
• Reactive towards: amino groups (primary amines)
• Longest of three similar imidoester crosslinkers, which include DMA, DMP and DMS
• Water-soluble
• Imidoesters react with amines at alkaline pH values (pH 8-10) to form amidine bond
• Amidine bond retains net charge character of protein primary amine to which it reacts
• Reversible at high pH values
• Tool for study of quarternary structure of proteins
Product References
Crosslinker Application Guide -- search for recent literature references for this product
Related Products
DMA (dimethyl adipimidate)
DMP (dimethyl pimelimidate)
DTBP (Wang and Richard's Reagent)
For Research Use Only. Not for use in diagnostic procedures.
規格
Cell PermeabilityYes
DescriptionDMS
FormPowder
Labeling MethodChemical Labeling
Molecular Weight (g/mol)273.2
PEGylatedNo
Product LinePierce
Quantity1 g
Reactive MoietyImidoester
Shipping ConditionAmbient
SolubilityWater
Spacer Arm Length11.0 Å
Water SolubleYes
Chemical ReactivityAmine-Amine
CleavableNo
Crosslinker TypeHomobifunctional
FormatStandard
Product TypeCrosslinker
SpacerMedium (10 to 30 Å)
Unit SizeEach
內容物與存放
Upon receipt store desiccated at 4°C.
常見問答集 (常見問題)
Can you provide the shelf-life for DMS (dimethyl suberimidate)?
引用資料與參考文獻 (5)
引用資料與參考文獻
Abstract
Discovery of lung cancer biomarkers by profiling the plasma proteome with monoclonal antibody libraries.
Journal:Mol Cell Proteomics
PubMed ID:21947365
'A challenge in the treatment of lung cancer is the lack of early diagnostics. Here, we describe the application of monoclonal antibody proteomics for discovery of a panel of biomarkers for early detection (stage I) of non-small cell lung cancer (NSCLC). We produced large monoclonal antibody libraries directed against the
The structural characterization of a prophage-encoded extracellular DNase from Streptococcus pyogenes.
Journal:Nucleic Acids Res
PubMed ID:21948797
'The pathogenic bacterium Group A Streptococcus pyogenes produces several extracellular DNases that have been shown to facilitate invasive infection by evading the human host immune system. DNases degrade the chromatin in neutrophil extracellular traps, enabling the bacterium to evade neutrophil capture. Spd1 is a type I, nonspecific ßßa/metal-dependent nuclease from
Outer membrane lipoprotein Lpp is Gram-negative bacterial cell surface receptor for cationic antimicrobial peptides.
Journal:J Biol Chem
PubMed ID:22084237
Antimicrobial peptides/proteins (AMPs) are important components of the host innate defense mechanisms. Here we demonstrate that the outer membrane lipoprotein, Lpp, of Enterobacteriaceae interacts with and promotes susceptibility to the bactericidal activities of AMPs. The oligomeric Lpp was specifically recognized by several cationic a-helical AMPs, including SMAP-29, CAP-18, and LL-37;
Inhibition of RNase L and RNA-dependent protein kinase (PKR) by sunitinib impairs antiviral innate immunity.
Journal:J Biol Chem
PubMed ID:21636578
RNase L and RNA-dependent protein kinase (PKR) are effectors of the interferon antiviral response that share homology in their pseudokinase and protein kinase domains, respectively. Sunitinib is an orally available, ATP-competitive inhibitor of VEGF and PDGF receptors used clinically to suppress angiogenesis and tumor growth. Sunitinib also impacts IRE1, an
Human mitochondrial DNA helicase TWINKLE is both an unwinding and annealing helicase.
Journal:J Biol Chem
PubMed ID:22383523
TWINKLE is a nucleus-encoded human mitochondrial (mt)DNA helicase. Point mutations in TWINKLE are associated with heritable neuromuscular diseases characterized by deletions in the mtDNA. To understand the biochemical basis of these diseases, it is important to define the roles of TWINKLE in mtDNA metabolism by studying its enzymatic activities. To