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Invitrogen

Nuclear Pore Complex Monoclonal Antibody (39C7)

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Product Details

MA5-33097

Applications
Tested Dilution
Publications

Immunocytochemistry (ICC/IF)

1:50-1:100
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Mouse / IgG1

Class

Monoclonal

Type

Antibody

Clone

39C7

Immunogen

Yeast nuclear preparations

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.25 mg/mL

Amount

25 µg

Storage buffer

tissue culture supernatant

Contains

10mM sodium azide

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2802647

Target Information

The nuclear pore complex (NPC) serves as the sole bidirectional gateway of macromolecules in and out of the nucleus. Each NPC consists of ~1,000 protein subunits, termed nucleoporins, and totals to a molecular mass of ~110 Mda. NPCs maintain the integrity of the nuclear compartment by preventing macromolecules from freely diffusing in or out of the nucleus. (Annu Rev Biochem, 2019. PMID 30883195)

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: 107 kDa nucleoporin; 133 kDa nucleoporin; 153 kDa nucleoporin; 155 kDa nucleoporin; 160 kDa nucleoporin; 205 kDa nucleoporin; 214 kDa nucleoporin; 35 kDa nucleoporin; 50 kDa nucleoporin; 62 kDa nucleoporin; 85 kDa nucleoporin; 88 kDa nuclear pore complex protein; 88 kDa nucleoporin; 93 kDa nucleoporin; 98 kDa nucleoporin; alternatively spliced; CAN protein, putative oncogene; CBP-interacting protein 4; FROUNT; Gene trap locus 1-13 protein; gene trap locus-13; GLFG-repeat containing nucleoporin; GTL-13; karyoporin; KIAA0023; KIAA0095; KIAA0225; Mitotic phosphoprotein 44; MP-44; Nuclear envelope pore membrane protein POM 210; nuclear pore associated protein 60 kDa; nuclear pore complex 1; nuclear pore complex protein 88; nuclear pore complex protein hnup153; Nuclear pore complex protein Nup107; Nuclear pore complex protein Nup133; Nuclear pore complex protein Nup153; Nuclear pore complex protein Nup155; Nuclear pore complex protein Nup160; Nuclear pore complex protein Nup205; Nuclear pore complex protein Nup214; Nuclear pore complex protein Nup50; Nuclear pore complex protein Nup53; Nuclear pore complex protein Nup85; Nuclear pore complex protein Nup88; Nuclear pore complex protein Nup93; nuclear pore complex protein Nup98; Nuclear pore complex protein Nup98-Nup96; nuclear pore glycoprotein 62; Nuclear pore glycoprotein p62; Nuclear pore membrane glycoprotein 210; nuclear pore membrane protein 210; Nuclear pore protein gp210; Nuclear pore-associated protein 60 kDa-like; nuclear pore-associated protein 60L; nucleoporin; nucleoporin 107kDa; nucleoporin 133; nucleoporin 133kD; nucleoporin 133kDa; nucleoporin 153kD; nucleoporin 153kDa; nucleoporin 155kD; nucleoporin 155kDa; nucleoporin 160kD; nucleoporin 160kDa; nucleoporin 205kDa; nucleoporin 210; nuclear pore membrane glycoprotein 210; nuclear pore membrane protein 210; nucleoporin 210kDa; nucleoporin 214kDa; nucleoporin 35kDa; nucleoporin 50 kDa; nucleoporin 50kD; nucleoporin 50kDa; nucleoporin 62kD; nucleoporin 62kDa; nucleoporin 85kDa; nucleoporin 88kDa; nucleoporin 93kDa; nucleoporin 96; nucleoporin 98kD; nucleoporin 98kDa; Nucleoporin Nup107; Nucleoporin Nup133; Nucleoporin Nup153; Nucleoporin Nup155; Nucleoporin Nup160; Nucleoporin Nup205; Nucleoporin Nup210; Nucleoporin Nup214; Nucleoporin NUP35; Nucleoporin Nup50; Nucleoporin NUP53; Nucleoporin Nup62; Nucleoporin Nup75; Nucleoporin Nup84; Nucleoporin Nup85; Nucleoporin Nup88; Nucleoporin Nup93; nucleoporin Nup98; nucleoprotein 50; Nucleoprotein 50kD; NUP50; NUP62; Nup98-Nup96; NUP98/PHF23 fusion 2 protein; p105; P140; pericentrin 1; Pericentrin-1; POM210; Pore membrane protein of 210 kDa; predicted protein of HQ1146; preimplantation protein 2; Protein CAN; unnamed protein product

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Gene Aliases: 160kDa; 1700030K07Rik; 2310006I24Rik; 2410008G02Rik; 2810011M03Rik; 35kDa; 3830404O05Rik; 4732457F17; 5330402E05Rik; 9830001L10; AA414952; AA589433; ADAR2; ADIR2; AI413123; AI426861; AI790512; AI836801; AI849286; ATFB15; AU020188; AU045898; AV248391; AW541137; B130015D15Rik; BC039282; C76801; C7orf14; C88147; CAIN; CAN; Cip4; D2H9S46E; D7Ertd649e; D930027M19Rik; FADS4; FROUNT; GAMOS7; GAMOS8; gp190; GP210; Gtl-13; Gtl1-13; Gtl13; hNUP133; HNUP153; IBSN; IIAE9; KIAA0023; KIAA0095; KIAA0197; KIAA0225; KIAA0791; KIAA0906; mermaid; mKIAA0197; mKIAA0225; mKIAA0791; MP-44; MP44; N153; N155; NIC96; NO44; NP44; Np62; NPAP60; NPAP60L; NPHS11; NPHS13; NPHS17; NPHS18; NPHS19; NUCZINK; NUP107; NUP120; NUP133; NUP153; NUP155; NUP160; NUP196; NUP205; NUP210; NUP214; NUP35; NUP50; NUP53; NUP62; NUP75; NUP84; NUP85; NUP88; NUP93; NUP96; NUP98; Nup98-96; Nupc1; ODG6; ODG6; GAMOS7; p62; PCNT1; POM210; Prei2; PRO1146; PSEC0245; RGD1304977; Rtp60; SNDI

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UniProt ID: (Human) P57740, (Human) Q8WUM0, (Human) P49790, (Human) O75694, (Human) Q12769, (Human) Q92621, (Human) Q8TEM1, (Human) P35658, (Human) Q8NFH5, (Human) Q9UKX7, (Human) P37198, (Human) Q9BW27, (Human) Q99567, (Human) Q8N1F7, (Human) P52948, (Rat) O08587, (Mouse) Q8BH74, (Mouse) Q8R0G9, (Mouse) E9Q3G8, (Rat) P37199, (Mouse) Q99P88, (Mouse) Q9Z0W3, (Rat) P11654, (Mouse) Q9QY81, (Mouse) Q80U93, (Rat) Q68FY1, (Mouse) Q8R4R6, (Mouse) Q9JIH2, (Rat) P17955, (Mouse) Q63850, (Rat) Q4QQS8, (Mouse) Q8R480, (Mouse) Q8CEC0, (Rat) O08658, (Mouse) Q8BJ71, (Rat) Q66HC5, (Mouse) Q6PFD9, (Rat) P49793

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Entrez Gene ID: (Human) 57122, (Human) 55746, (Human) 9972, (Human) 9631, (Human) 23279, (Human) 23165, (Human) 23225, (Human) 8021, (Human) 129401, (Human) 10762, (Human) 23636, (Human) 79902, (Human) 4927, (Human) 9688, (Human) 4928, (Rat) 25497, (Rat) 116555, (Mouse) 103468, (Mouse) 234865, (Rat) 292085, (Rat) 25281, (Mouse) 218210, (Rat) 117021, (Mouse) 170762, (Mouse) 59015, (Rat) 311182, (Mouse) 70699, (Rat) 362335, (Rat) 58958, (Mouse) 54563, (Mouse) 227720, (Rat) 296634, (Rat) 295692, (Mouse) 69482, (Mouse) 18141, (Rat) 65274, (Mouse) 18226, (Rat) 287830, (Mouse) 445007, (Mouse) 19069, (Rat) 113929, (Mouse) 71805, (Rat) 291874, (Mouse) 269966, (Rat) 81738

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Function(s)
protein binding structural constituent of nuclear pore DNA binding nuclear localization sequence binding zinc ion binding identical protein binding protein anchor metal ion binding molecular condensate scaffold activity nuclear export signal receptor activity nucleic acid binding phospholipid binding chromatin binding receptor signaling complex scaffold activity Hsp70 protein binding SH2 domain binding ubiquitin binding PTB domain binding Hsp90 protein binding transcription coactivator activity RNA binding mRNA binding peptidase activity serine-type peptidase activity hydrolase activity peptide binding promoter-specific chromatin binding nucleocytoplasmic transporter activity porin activity Ran GTPase binding protein dimerization activity protein homodimerization activity thyroid hormone receptor binding kinesin binding CCR2 chemokine receptor binding transporter scaffold/adaptor protein structural protein
Process(es)
posttranscriptional tethering of RNA polymerase II gene DNA at nuclear periphery mRNA export from nucleus protein import into nucleus nucleocytoplasmic transport female gonad development protein transport mRNA transport nuclear pore complex assembly nephron development transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery nuclear pore organization poly(A)+ mRNA export from nucleus neural tube development neurogenesis paraxial mesoderm development animal organ development system development somite development RNA export from nucleus viral entry into host cell negative regulation of RNA export from nucleus viral penetration into host nucleus amyloid fibril formation nuclear envelope organization protein localization to nucleus production of miRNAs involved in gene silencing by miRNA protein targeting to nuclear inner membrane atrial cardiac muscle cell action potential protein export from nucleus intracellular protein transport regulation of nucleocytoplasmic transport regulation of cell cycle NLS-bearing protein import into nucleus cellular response to leukemia inhibitory factor neural tube formation mitotic metaphase plate congression centrosome cycle mitotic centrosome separation cell surface receptor signaling pathway negative regulation of cell proliferation regulation of signal transduction negative regulation of epidermal growth factor receptor signaling pathway negative regulation of apoptotic process negative regulation of programmed cell death positive regulation of I-kappaB kinase/NF-kappaB signaling positive regulation of epidermal growth factor receptor signaling pathway positive regulation of mitotic nuclear division positive regulation of transcription, DNA-templated regulation of Ras protein signal transduction negative regulation of Ras protein signal transduction positive regulation of centriole replication regulation of mitotic spindle organization cellular senescence centriole assembly positive regulation of mitotic cytokinetic process positive regulation of protein localization to centrosome chemotaxis lamellipodium assembly macrophage chemotaxis ribosomal large subunit export from nucleus ribosomal small subunit export from nucleus positive regulation of SMAD protein import into nucleus proteolysis telomere tethering at nuclear periphery positive regulation of mRNA splicing, via spliceosome intracellular transport transmembrane transport transport biological_process transcription, DNA-templated cell aging cell death negative regulation of MAP kinase activity cell migration cytokine-mediated signaling pathway positive regulation of defense response to virus by host mitophagy in response to mitochondrial depolarization protein import into nucleus, docking DNA replication
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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