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          System Message

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          LOADING ...
          Gene:
          SMAD3
          Transcript:
          NM_001145103.1
          Assay Name:
          Mutation genome location:
          chr.15 67164762-67165325 on build GRCh38
          Assay ID Hs00469007_CE

          Purification
          Size
          Availability Made To Order
          Catalog # A15629
          Price
          Your Price
          Online offer:
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          • Genomic Map
          • Assay Details
          • More Information

          Genomic Map

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          Assay Details


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          More Information


          Set Membership:

          Between 400-700 bp

          Panther Classification:

          Molecular Function -

          DNA-binding transcription factor gene-specific transcriptional regulator

          Gene Ontology Categories:

          Function(s) Process(es)

          negative regulation of transcription from RNA polymerase II promoter
          ureteric bud development
          response to hypoxia
          in utero embryonic development
          mesoderm formation
          somitogenesis
          liver development
          heart looping
          osteoblast development
          immune system development
          transcription, DNA-templated
          regulation of transcription from RNA polymerase II promoter
          transport
          activation of cysteine-type endopeptidase activity involved in apoptotic process
          immune response
          cell cycle arrest
          transforming growth factor beta receptor signaling pathway
          SMAD protein complex assembly
          endoderm development
          embryonic pattern specification
          positive regulation of gene expression
          positive regulation of alkaline phosphatase activity
          positive regulation of epithelial to mesenchymal transition
          regulation of striated muscle tissue development
          regulation of transforming growth factor beta receptor signaling pathway
          evasion or tolerance of host defenses by virus
          signal transduction involved in regulation of gene expression
          negative regulation of cell growth
          positive regulation of cell migration
          positive regulation of bone mineralization
          negative regulation of transforming growth factor beta receptor signaling pathway
          thyroid gland development
          primary miRNA processing
          positive regulation of chondrocyte differentiation
          positive regulation of interleukin-1 beta production
          regulation of transforming growth factor beta2 production
          positive regulation of transforming growth factor beta3 production
          activin receptor signaling pathway
          negative regulation of osteoblast proliferation
          nodal signaling pathway
          wound healing
          T cell activation
          positive regulation of transcription factor import into nucleus
          negative regulation of apoptotic process
          cell-cell junction organization
          negative regulation of fat cell differentiation
          negative regulation of osteoblast differentiation
          positive regulation of transcription, DNA-templated
          negative regulation of mitotic cell cycle
          positive regulation of transcription from RNA polymerase II promoter
          paraxial mesoderm morphogenesis
          developmental growth
          embryonic foregut morphogenesis
          embryonic cranial skeleton morphogenesis
          regulation of epithelial cell proliferation
          negative regulation of inflammatory response
          regulation of immune response
          positive regulation of positive chemotaxis
          regulation of binding
          positive regulation of stress fiber assembly
          positive regulation of focal adhesion assembly
          pericardium development
          transdifferentiation
          SMAD protein signal transduction
          negative regulation of wound healing
          lens fiber cell differentiation
          extrinsic apoptotic signaling pathway
          activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway
          positive regulation of extracellular matrix assembly
          RNA polymerase II core promoter proximal region sequence-specific DNA binding
          transcription factor activity, RNA polymerase II core promoter sequence-specific
          core promoter proximal region sequence-specific DNA binding
          transcription factor activity, protein binding
          RNA polymerase II activating transcription factor binding
          transcription factor activity, sequence-specific DNA binding
          transforming growth factor beta receptor binding
          protein binding
          collagen binding
          transcription factor binding
          zinc ion binding
          protein kinase binding
          phosphatase binding
          transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity
          chromatin DNA binding
          ubiquitin protein ligase binding
          enhancer binding
          identical protein binding
          protein homodimerization activity
          ubiquitin binding
          bHLH transcription factor binding
          sequence-specific DNA binding
          transcription regulatory region DNA binding
          protein heterodimerization activity
          co-SMAD binding
          R-SMAD binding

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          Host server : magellan-search-green-b49b87d85-pgj68:80/100.66.79.163:80.
          git-commit: 5b8c860b7cdb41e9cfe07630520f6b51e109d38e
          git-url: https://github.com/thermofisher/magellan-search
          git-branch: release/2.47.0-Offline