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          • Home
          • › Search Tool
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          • › Hs00356618_m1
          See other INS GE Assays ›
          Gene Symbol:
          INS
          Gene Name:
          insulin
          Gene Aliases:
          IDDM, IDDM1, IDDM2, ILPR, IRDN, MODY10
          Chromosome Location:
          Chr.11: 2159779 - 2161209 on Build GRCh38
          Species:
          Human
          Species Specific ID (Flybase ID):
          -
          Assay ID Hs00356618_m1
          Size
          Availability Inventoried
          Catalog # 4331182
          Price
          Your Price
          Online offer:
          Check your price ›
          • Genomic Map
          • Assay Details
          • More Information

          Genomic Map

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          Assay Details

          Gene Symbol: INS
          Interrogated Sequence Translated Protein Exon Boundary Assay Location IMAGE Clone ID Amplicon Length
          RefSeq NM_000207.2 NP_000198.1 2 - 3 245 146
          NM_001185097.1 NP_001172026.1 2 - 3 271 146
          NM_001185098.1 NP_001172027.1 1 - 2 424 146
          NM_001291897.1 NP_001278826.1 2 - 3 305 146
          GenBank mRNA AY899304.1 - 2 - 3 241 146
          BC005255.1 - 2 - 3 245 3950204 146
          BM510347.1 - 2 - 3 266 146
          BM510748.1 - 2 - 3 249 146
          BP322143.1 - 1 - 2 424 146
          BT006808.1 - 1 - 2 186 146
          JF909299.1 - 1 - 2 139 146
          JQ951950.1 - 2 - 3 230 146
          X70508.1 - 2 - 3 230 146

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          More Information


          Updated Mapping Information

          This assay targets the same location as Clariom D transcript cluster(s) TC1100013132.hg.1
          This assay targets the same location as HTA transcript cluster(s) TC11001274.hg.1

          Set Membership:

          Ambion siRNA available Amplicon length greater than or equal to 101 Mammalian Gene Collection Homo sapiens Inventoried Probe spans exons

          Matching Ambion siRNAs:

          Click here to find siRNAs for Gene INS

          Panther Classification:

          Molecular Function -

          growth factor

          Gene Ontology Categories:

          Function(s) Process(es)

          MAPK cascade
          negative regulation of acute inflammatory response
          glucose metabolic process
          regulation of transcription, DNA-templated
          regulation of cellular amino acid metabolic process
          ER to Golgi vesicle-mediated transport
          acute-phase response
          G-protein coupled receptor signaling pathway
          cell-cell signaling
          positive regulation of cell proliferation
          insulin receptor signaling pathway
          positive regulation of gene expression
          positive regulation of phosphatidylinositol 3-kinase signaling
          glucose transport
          regulation of transmembrane transporter activity
          positive regulation of cell growth
          positive regulation of cell migration
          positive regulation of protein autophosphorylation
          activation of protein kinase B activity
          positive regulation of cellular protein metabolic process
          negative regulation of protein oligomerization
          regulation of protein localization
          negative regulation of NAD(P)H oxidase activity
          wound healing
          negative regulation of protein catabolic process
          glucose homeostasis
          positive regulation of MAPK cascade
          cellular protein metabolic process
          positive regulation of nitric oxide biosynthetic process
          positive regulation of cell differentiation
          negative regulation of gluconeogenesis
          positive regulation of glycogen biosynthetic process
          positive regulation of DNA replication
          negative regulation of glycogen catabolic process
          positive regulation of glycolytic process
          positive regulation of mitotic nuclear division
          negative regulation of proteolysis
          negative regulation of vasodilation
          positive regulation of vasodilation
          negative regulation of fatty acid metabolic process
          positive regulation of glucose import
          positive regulation of insulin receptor signaling pathway
          alpha-beta T cell activation
          positive regulation of lipid biosynthetic process
          regulation of protein secretion
          negative regulation of protein secretion
          positive regulation of cytokine secretion
          positive regulation of peptidyl-tyrosine phosphorylation
          negative regulation of lipid catabolic process
          positive regulation of nitric-oxide synthase activity
          positive regulation of NF-kappaB transcription factor activity
          positive regulation of protein kinase B signaling
          fatty acid homeostasis
          negative regulation of respiratory burst involved in inflammatory response
          positive regulation of respiratory burst
          positive regulation of peptide hormone secretion
          positive regulation of brown fat cell differentiation
          positive regulation of protein localization to nucleus
          negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
          negative regulation of feeding behavior
          protease binding
          insulin receptor binding
          insulin-like growth factor receptor binding
          hormone activity
          protein binding
          identical protein binding

          MicroArray Probes:

          Affymetrix

          Array Name Probe IDs Targets Target Type
          Affymetrix Human Transcriptome Array 2.0 PSR11016151.hg.1 ENST00000397262.1 Ensembl
          Affymetrix Human Transcriptome Array 2.0 PSR11016151.hg.1 NM_001185098.1 Refseq
          Affymetrix Human Transcriptome Array 2.0 PSR11016151.hg.1 TC11001274.hg.1 HTA TC
          Affymetrix Human Transcriptome Array 2.0 TC1100013132.hg.1 ENST00000250971.7 Ensembl
          Affymetrix Human Transcriptome Array 2.0 TC1100013132.hg.1 ENST00000250971.7 Ensembl
          Affymetrix Human Transcriptome Array 2.0 TC1100013132.hg.1 ENST00000250971.7 Ensembl
          Affymetrix Human Transcriptome Array 2.0 TC1100013132.hg.1 ENST00000250971.7 Ensembl
          Affymetrix Human Transcriptome Array 2.0 TC1100013132.hg.1 ENST00000250971.7 Ensembl
          Affymetrix Human Transcriptome Array 2.0 TC1100013132.hg.1 ENST00000381330.4 Ensembl
          Affymetrix Human Transcriptome Array 2.0 TC1100013132.hg.1 ENST00000381330.4 Ensembl
          Affymetrix Human Transcriptome Array 2.0 TC1100013132.hg.1 ENST00000381330.4 Ensembl
          Affymetrix Human Transcriptome Array 2.0 TC1100013132.hg.1 ENST00000381330.4 Ensembl
          Affymetrix Human Transcriptome Array 2.0 TC1100013132.hg.1 ENST00000381330.4 Ensembl
          Affymetrix Human Transcriptome Array 2.0 TC1100013132.hg.1 ENST00000381330.4 Ensembl
          Affymetrix Human Transcriptome Array 2.0 TC1100013132.hg.1 ENST00000397262.5 Ensembl
          Affymetrix Human Transcriptome Array 2.0 TC1100013132.hg.1 ENST00000397262.5 Ensembl
          Affymetrix Human Transcriptome Array 2.0 TC1100013132.hg.1 ENST00000397262.5 Ensembl
          Affymetrix Human Transcriptome Array 2.0 TC1100013132.hg.1 ENST00000397262.5 Ensembl
          Affymetrix Human Transcriptome Array 2.0 TC1100013132.hg.1 ENST00000397262.5 Ensembl
          Affymetrix Human Transcriptome Array 2.0 TC1100013132.hg.1 ENST00000397262.5 Ensembl
          Affymetrix Human Transcriptome Array 2.0 TC1100013132.hg.1 ENST00000397262.5 Ensembl
          Affymetrix Human Transcriptome Array 2.0 TC1100013132.hg.1 ENST00000397270.1 Ensembl
          Affymetrix Human Transcriptome Array 2.0 TC1100013132.hg.1 ENST00000397270.1 Ensembl
          Affymetrix Human Transcriptome Array 2.0 TC1100013132.hg.1 ENST00000397270.1 Ensembl
          Affymetrix Human Transcriptome Array 2.0 TC1100013132.hg.1 ENST00000397270.1 Ensembl
          Affymetrix Human Transcriptome Array 2.0 TC1100013132.hg.1 ENST00000397270.1 Ensembl
          Affymetrix Human Transcriptome Array 2.0 TC1100013132.hg.1 ENST00000397270.1 Ensembl
          Affymetrix Human Transcriptome Array 2.0 TC1100013132.hg.1 ENST00000421783.1 Ensembl
          Affymetrix Human Transcriptome Array 2.0 TC1100013132.hg.1 ENST00000421783.1 Ensembl
          Affymetrix Human Transcriptome Array 2.0 TC1100013132.hg.1 ENST00000421783.1 Ensembl
          Affymetrix Human Transcriptome Array 2.0 TC1100013132.hg.1 ENST00000421783.1 Ensembl
          Affymetrix Human Transcriptome Array 2.0 TC1100013132.hg.1 ENST00000476874.1 Ensembl
          Affymetrix Human Transcriptome Array 2.0 TC1100013132.hg.1 ENST00000476874.1 Ensembl
          Affymetrix Human Transcriptome Array 2.0 TC1100013132.hg.1 ENST00000476874.1 Ensembl
          Affymetrix Human Transcriptome Array 2.0 TC1100013132.hg.1 ENST00000481781.1 Ensembl
          Affymetrix Human Transcriptome Array 2.0 TC1100013132.hg.1 ENST00000481781.1 Ensembl
          Affymetrix Human Transcriptome Array 2.0 TC1100013132.hg.1 ENST00000481781.1 Ensembl
          Affymetrix Human Transcriptome Array 2.0 TC1100013132.hg.1 ENST00000481781.1 Ensembl
          Affymetrix Human Transcriptome Array 2.0 TC1100013132.hg.1 ENST00000481781.1 Ensembl
          Affymetrix Human Transcriptome Array 2.0 TC1100013132.hg.1 ENST00000481781.1 Ensembl
          Affymetrix Human Transcriptome Array 2.0 TC1100013132.hg.1 ENST00000512523.1 Ensembl
          Affymetrix Human Transcriptome Array 2.0 TC1100013132.hg.1 ENST00000512523.1 Ensembl
          Affymetrix Human Transcriptome Array 2.0 TC1100013132.hg.1 NM_000207.2 Refseq
          Affymetrix Human Transcriptome Array 2.0 TC1100013132.hg.1 NM_000207.2 Refseq
          Affymetrix Human Transcriptome Array 2.0 TC1100013132.hg.1 NM_000207.2 Refseq
          Affymetrix Human Transcriptome Array 2.0 TC1100013132.hg.1 NM_000207.2 Refseq
          Affymetrix Human Transcriptome Array 2.0 TC1100013132.hg.1 NM_000207.2 Refseq
          Affymetrix Human Transcriptome Array 2.0 TC1100013132.hg.1 NM_001042376.2 Refseq
          Affymetrix Human Transcriptome Array 2.0 TC1100013132.hg.1 NM_001042376.2 Refseq
          Affymetrix Human Transcriptome Array 2.0 TC1100013132.hg.1 NM_001042376.2 Refseq
          Affymetrix Human Transcriptome Array 2.0 TC1100013132.hg.1 NM_001042376.2 Refseq
          Affymetrix Human Transcriptome Array 2.0 TC1100013132.hg.1 NM_001042376.2 Refseq
          Affymetrix Human Transcriptome Array 2.0 TC1100013132.hg.1 NM_001042376.2 Refseq
          Affymetrix Human Transcriptome Array 2.0 TC1100013132.hg.1 NM_001185097.1 Refseq
          Affymetrix Human Transcriptome Array 2.0 TC1100013132.hg.1 NM_001185097.1 Refseq
          Affymetrix Human Transcriptome Array 2.0 TC1100013132.hg.1 NM_001185097.1 Refseq
          Affymetrix Human Transcriptome Array 2.0 TC1100013132.hg.1 NM_001185097.1 Refseq
          Affymetrix Human Transcriptome Array 2.0 TC1100013132.hg.1 NM_001185097.1 Refseq
          Affymetrix Human Transcriptome Array 2.0 TC1100013132.hg.1 NM_001185098.1 Refseq
          Affymetrix Human Transcriptome Array 2.0 TC1100013132.hg.1 NM_001185098.1 Refseq
          Affymetrix Human Transcriptome Array 2.0 TC1100013132.hg.1 NM_001185098.1 Refseq
          Affymetrix Human Transcriptome Array 2.0 TC1100013132.hg.1 NM_001185098.1 Refseq
          Affymetrix Human Transcriptome Array 2.0 TC1100013132.hg.1 NM_001185098.1 Refseq
          Affymetrix Human Transcriptome Array 2.0 TC1100013132.hg.1 NM_001185098.1 Refseq
          Affymetrix Human Transcriptome Array 2.0 TC1100013132.hg.1 NM_001185098.1 Refseq
          Affymetrix Human Transcriptome Array 2.0 TC1100013132.hg.1 NM_001291897.1 Refseq
          Affymetrix Human Transcriptome Array 2.0 TC1100013132.hg.1 NM_001291897.1 Refseq
          Affymetrix Human Transcriptome Array 2.0 TC1100013132.hg.1 NM_001291897.1 Refseq
          Affymetrix Human Transcriptome Array 2.0 TC1100013132.hg.1 NM_001291897.1 Refseq
          Affymetrix Human Transcriptome Array 2.0 TC1100013132.hg.1 NM_001291897.1 Refseq
          Affymetrix Human Transcriptome Array 2.0 TC1100013132.hg.1 NM_001291897.1 Refseq
          Affymetrix Human Transcriptome Array 2.0 PSR11016147.hg.1 ENST00000250971.3 Ensembl
          Affymetrix Human Transcriptome Array 2.0 PSR11016147.hg.1 ENST00000381330.4 Ensembl
          Affymetrix Human Transcriptome Array 2.0 PSR11016147.hg.1 ENST00000397262.1 Ensembl
          Affymetrix Human Transcriptome Array 2.0 PSR11016147.hg.1 NM_000207.2 Refseq
          Affymetrix Human Transcriptome Array 2.0 PSR11016147.hg.1 NM_001185097.1 Refseq
          Affymetrix Human Transcriptome Array 2.0 PSR11016147.hg.1 NM_001185098.1 Refseq
          Affymetrix Human Transcriptome Array 2.0 PSR11016147.hg.1 TC11001274.hg.1 HTA TC
          Affymetrix Human Clariom D Assay PSR1100203363.hg.1 ENST00000397262.5 Ensembl
          Affymetrix Human Clariom D Assay PSR1100203363.hg.1 ENST00000421783.1 Ensembl
          Affymetrix Human Clariom D Assay PSR1100203363.hg.1 NM_001185098.1 Refseq
          Affymetrix Human Clariom D Assay PSR1100203363.hg.1 ENST00000397262.5 Ensembl
          Affymetrix Human Clariom D Assay PSR1100203363.hg.1 ENST00000421783.1 Ensembl
          Affymetrix Human Clariom D Assay PSR1100203363.hg.1 NM_001185098.1 Refseq
          Affymetrix Human Clariom D Assay PSR1100203363.hg.1 TC1100013132.hg.1 Clariom D TC
          Affymetrix Human Clariom D Assay PSR1100203359.hg.1 ENST00000250971.7 Ensembl
          Affymetrix Human Clariom D Assay PSR1100203359.hg.1 ENST00000381330.4 Ensembl
          Affymetrix Human Clariom D Assay PSR1100203359.hg.1 ENST00000397262.5 Ensembl
          Affymetrix Human Clariom D Assay PSR1100203359.hg.1 NM_000207.2 Refseq
          Affymetrix Human Clariom D Assay PSR1100203359.hg.1 NM_001185097.1 Refseq
          Affymetrix Human Clariom D Assay PSR1100203359.hg.1 NM_001185098.1 Refseq
          Affymetrix Human Clariom D Assay PSR1100203359.hg.1 NM_001291897.1 Refseq
          Affymetrix Human Clariom D Assay PSR1100203359.hg.1 ENST00000250971.7 Ensembl
          Affymetrix Human Clariom D Assay PSR1100203359.hg.1 ENST00000381330.4 Ensembl
          Affymetrix Human Clariom D Assay PSR1100203359.hg.1 ENST00000397262.5 Ensembl
          Affymetrix Human Clariom D Assay PSR1100203359.hg.1 NM_000207.2 Refseq
          Affymetrix Human Clariom D Assay PSR1100203359.hg.1 NM_001185097.1 Refseq
          Affymetrix Human Clariom D Assay PSR1100203359.hg.1 NM_001185098.1 Refseq
          Affymetrix Human Clariom D Assay PSR1100203359.hg.1 NM_001291897.1 Refseq
          Affymetrix Human Clariom D Assay PSR1100203359.hg.1 TC1100013132.hg.1 Clariom D TC
          Affymetrix Human Clariom D Assay TC1100013132.hg.1 ENST00000250971.7 Ensembl
          Affymetrix Human Clariom D Assay TC1100013132.hg.1 ENST00000250971.7 Ensembl
          Affymetrix Human Clariom D Assay TC1100013132.hg.1 ENST00000250971.7 Ensembl
          Affymetrix Human Clariom D Assay TC1100013132.hg.1 ENST00000250971.7 Ensembl
          Affymetrix Human Clariom D Assay TC1100013132.hg.1 ENST00000250971.7 Ensembl
          Affymetrix Human Clariom D Assay TC1100013132.hg.1 ENST00000381330.4 Ensembl
          Affymetrix Human Clariom D Assay TC1100013132.hg.1 ENST00000381330.4 Ensembl
          Affymetrix Human Clariom D Assay TC1100013132.hg.1 ENST00000381330.4 Ensembl
          Affymetrix Human Clariom D Assay TC1100013132.hg.1 ENST00000381330.4 Ensembl
          Affymetrix Human Clariom D Assay TC1100013132.hg.1 ENST00000381330.4 Ensembl
          Affymetrix Human Clariom D Assay TC1100013132.hg.1 ENST00000381330.4 Ensembl
          Affymetrix Human Clariom D Assay TC1100013132.hg.1 ENST00000397262.5 Ensembl
          Affymetrix Human Clariom D Assay TC1100013132.hg.1 ENST00000397262.5 Ensembl
          Affymetrix Human Clariom D Assay TC1100013132.hg.1 ENST00000397262.5 Ensembl
          Affymetrix Human Clariom D Assay TC1100013132.hg.1 ENST00000397262.5 Ensembl
          Affymetrix Human Clariom D Assay TC1100013132.hg.1 ENST00000397262.5 Ensembl
          Affymetrix Human Clariom D Assay TC1100013132.hg.1 ENST00000397262.5 Ensembl
          Affymetrix Human Clariom D Assay TC1100013132.hg.1 ENST00000397262.5 Ensembl
          Affymetrix Human Clariom D Assay TC1100013132.hg.1 ENST00000397270.1 Ensembl
          Affymetrix Human Clariom D Assay TC1100013132.hg.1 ENST00000397270.1 Ensembl
          Affymetrix Human Clariom D Assay TC1100013132.hg.1 ENST00000397270.1 Ensembl
          Affymetrix Human Clariom D Assay TC1100013132.hg.1 ENST00000397270.1 Ensembl
          Affymetrix Human Clariom D Assay TC1100013132.hg.1 ENST00000397270.1 Ensembl
          Affymetrix Human Clariom D Assay TC1100013132.hg.1 ENST00000397270.1 Ensembl
          Affymetrix Human Clariom D Assay TC1100013132.hg.1 ENST00000421783.1 Ensembl
          Affymetrix Human Clariom D Assay TC1100013132.hg.1 ENST00000421783.1 Ensembl
          Affymetrix Human Clariom D Assay TC1100013132.hg.1 ENST00000421783.1 Ensembl
          Affymetrix Human Clariom D Assay TC1100013132.hg.1 ENST00000421783.1 Ensembl
          Affymetrix Human Clariom D Assay TC1100013132.hg.1 ENST00000476874.1 Ensembl
          Affymetrix Human Clariom D Assay TC1100013132.hg.1 ENST00000476874.1 Ensembl
          Affymetrix Human Clariom D Assay TC1100013132.hg.1 ENST00000476874.1 Ensembl
          Affymetrix Human Clariom D Assay TC1100013132.hg.1 ENST00000481781.1 Ensembl
          Affymetrix Human Clariom D Assay TC1100013132.hg.1 ENST00000481781.1 Ensembl
          Affymetrix Human Clariom D Assay TC1100013132.hg.1 ENST00000481781.1 Ensembl
          Affymetrix Human Clariom D Assay TC1100013132.hg.1 ENST00000481781.1 Ensembl
          Affymetrix Human Clariom D Assay TC1100013132.hg.1 ENST00000481781.1 Ensembl
          Affymetrix Human Clariom D Assay TC1100013132.hg.1 ENST00000481781.1 Ensembl
          Affymetrix Human Clariom D Assay TC1100013132.hg.1 ENST00000512523.1 Ensembl
          Affymetrix Human Clariom D Assay TC1100013132.hg.1 ENST00000512523.1 Ensembl
          Affymetrix Human Clariom D Assay TC1100013132.hg.1 NM_000207.2 Refseq
          Affymetrix Human Clariom D Assay TC1100013132.hg.1 NM_000207.2 Refseq
          Affymetrix Human Clariom D Assay TC1100013132.hg.1 NM_000207.2 Refseq
          Affymetrix Human Clariom D Assay TC1100013132.hg.1 NM_000207.2 Refseq
          Affymetrix Human Clariom D Assay TC1100013132.hg.1 NM_000207.2 Refseq
          Affymetrix Human Clariom D Assay TC1100013132.hg.1 NM_001042376.2 Refseq
          Affymetrix Human Clariom D Assay TC1100013132.hg.1 NM_001042376.2 Refseq
          Affymetrix Human Clariom D Assay TC1100013132.hg.1 NM_001042376.2 Refseq
          Affymetrix Human Clariom D Assay TC1100013132.hg.1 NM_001042376.2 Refseq
          Affymetrix Human Clariom D Assay TC1100013132.hg.1 NM_001042376.2 Refseq
          Affymetrix Human Clariom D Assay TC1100013132.hg.1 NM_001042376.2 Refseq
          Affymetrix Human Clariom D Assay TC1100013132.hg.1 NM_001185097.1 Refseq
          Affymetrix Human Clariom D Assay TC1100013132.hg.1 NM_001185097.1 Refseq
          Affymetrix Human Clariom D Assay TC1100013132.hg.1 NM_001185097.1 Refseq
          Affymetrix Human Clariom D Assay TC1100013132.hg.1 NM_001185097.1 Refseq
          Affymetrix Human Clariom D Assay TC1100013132.hg.1 NM_001185097.1 Refseq
          Affymetrix Human Clariom D Assay TC1100013132.hg.1 NM_001185098.1 Refseq
          Affymetrix Human Clariom D Assay TC1100013132.hg.1 NM_001185098.1 Refseq
          Affymetrix Human Clariom D Assay TC1100013132.hg.1 NM_001185098.1 Refseq
          Affymetrix Human Clariom D Assay TC1100013132.hg.1 NM_001185098.1 Refseq
          Affymetrix Human Clariom D Assay TC1100013132.hg.1 NM_001185098.1 Refseq
          Affymetrix Human Clariom D Assay TC1100013132.hg.1 NM_001185098.1 Refseq
          Affymetrix Human Clariom D Assay TC1100013132.hg.1 NM_001185098.1 Refseq
          Affymetrix Human Clariom D Assay TC1100013132.hg.1 NM_001291897.1 Refseq
          Affymetrix Human Clariom D Assay TC1100013132.hg.1 NM_001291897.1 Refseq
          Affymetrix Human Clariom D Assay TC1100013132.hg.1 NM_001291897.1 Refseq
          Affymetrix Human Clariom D Assay TC1100013132.hg.1 NM_001291897.1 Refseq
          Affymetrix Human Clariom D Assay TC1100013132.hg.1 NM_001291897.1 Refseq
          Affymetrix Human Clariom D Assay TC1100013132.hg.1 NM_001291897.1 Refseq
          Affymetrix Human Clariom D Assay PSR1100203364.hg.1 ENST00000397262.5 Ensembl
          Affymetrix Human Clariom D Assay PSR1100203364.hg.1 ENST00000421783.1 Ensembl
          Affymetrix Human Clariom D Assay PSR1100203364.hg.1 NM_001185098.1 Refseq
          Affymetrix Human Clariom D Assay PSR1100203364.hg.1 NM_001291897.1 Refseq
          Affymetrix Human Clariom D Assay PSR1100203364.hg.1 ENST00000397262.5 Ensembl
          Affymetrix Human Clariom D Assay PSR1100203364.hg.1 ENST00000421783.1 Ensembl
          Affymetrix Human Clariom D Assay PSR1100203364.hg.1 NM_001185098.1 Refseq
          Affymetrix Human Clariom D Assay PSR1100203364.hg.1 NM_001291897.1 Refseq
          Affymetrix Human Clariom D Assay PSR1100203364.hg.1 TC1100013132.hg.1 Clariom D TC

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          Host server : magellan-search-green-b49b87d85-n9r8p:80/100.66.76.150:80.
          git-commit: 5b8c860b7cdb41e9cfe07630520f6b51e109d38e
          git-url: https://github.com/thermofisher/magellan-search
          git-branch: release/2.47.0-Offline