Applications of the Volumescope 2 SEM in biological research

The Thermo Scientific Volumescope 2 SEM is a versatile imaging tool designed for a wide range of scientific applications. This workhorse solution provides high-resolution, 3D imaging for the sub-surface visualization of biological samples, helping to uncover the complex structures that define biological function. The Volumescope 2 SEM unlocks previously inaccessible insights in fields such as cell and tissue biology, neuroscience, infectious disease research, plant biology, and more. You can visualize not only tissue architecture but also subcellular detail in three dimensions, providing exciting new insights for a wide range of biological specimens.


Neuroscience applications of the Volumescope 2 SEM

The Volumescope 2 SEM provides high-resolution, automated 3D imaging of brain tissue. Its ability to capture large volumes with precision and ease enables researchers to map neural circuits and understand complex brain structures in unprecedented detail. This tool enhances the study of neurological function, development, and disease, offering critical 3D insights for a wide variety of brain tissues.


Cell biology applications of the Volumescope 2 SEM

3D visualization of large sample volumes enables the nanoscale, cellular and subcellular exploration of organelles, along with their organization and interactions. This facilitates the study of cellular processes, disease mechanisms, and the intricate architecture of tissues, providing critical insights for cell biology and biomedical research. 


Infectious disease research with the Volumescope 2 SEM

Analysis of pathogen-host interactions is critical for a holistic understanding of infection and replication mechanisms. Using the Volumescope 2 SEM, large cell and tissue volumes can be visualized for the study of viruses, bacteria, and other pathogens within infected specimens. This aids in the analysis of infection mechanisms along with pathogen behavior and immune response, providing a range of critical information that can contribute to the development of treatments.

Cowpox virus infected cells

Cells infected with cowpox virus, imaged with the Volumescope 2 SEM. Amira Software was used to segment the 3D data, showing virus particles (yellow and orange) as well as nuclei (green). Sample courtesy of the Robert Koch Institute, Germany.


Tissue research using the Volumescope 2 SEM

The Volumescope 2 SEM can visualize large volumes of tissues such as kidney, lung, skin, brain, and liver, and can even view whole model organisms such as zebrafish and c. elegans

 

By capturing the structural details of these varied sample types, the Volumescope 2 SEM can support the study of different genetic models, disease pathology, as well as tissue development and regeneration.


Understanding the ultrastructure of plant cells with the Volumescope 2 SEM

The Volumescope 2 SEM enables the automated visualization of large plant cell and tissue volumes at high resolution.

 

This information provides a better understanding of cellular processes, plant development, plant-pathogen interactions, and responses to environmental stresses. 

 

For Research Use Only. Not for use in diagnostic procedures.