Reliable solutions for accelerating small molecule drug development

 

By leveraging exciting new technologies at the leading edge of precision medicine, you’re helping to potentially stop some of the world’s deadliest diseases in their tracks. We have gathered feedback and  know in order to speed these promising therapeutics to market, you’re committed to ensuring a high degree of accuracy and safety from discovery to commercialization of your small molecule drug.

We know you need a high-throughput screening method that’s biologically relevant, efficient, and sensitive, and an assay robust enough to determine accurate pharmacology. And by the time you’re ready to move to phase I clinical trials, we know you need to be confident that your drug is safe.

From CRISPR-Cas9 gene editing tools and transfection reagents to SelectScreen services and cell culture media, we provide expertise and an unparalleled array of scalable tools, services, and support designed to deliver high-quality results and accelerate your productivity and innovation. We are the partner you need to bring your small molecule drug to market with the goal of improving health care for millions of people.

View our comprehensive list of products, services, and technologies to support you at every step of small molecule drug development:
 

Target Identification MethodsTarget discovery

Target-based drug discovery identifies a new therapeutic target, then screens for a drug that binds to it. Target deconvolution begins with a drug that is efficacious in phenotypic studies and retrospectively identifies the target.

Featured products

Genetic analysis

Sequencing solutions


Wide range of sequencing solutions from gold-standard Sanger sequencing technology, to flexible and scalable next-generation sequencing (NGS) products.

Discover more

NGS library preparation kits for Illumina platforms

Generate libraries more quickly, with less bias, in order to match the speed and capacity of Illumina instruments.
 

Discover more

Gene expression analysis using RNA sequencing

From targeted gene expression analysis to whole transcriptome sequencing, combine simple sample preparation and intuitive data analysis.

Discover more

Gene expression analysis using qPCR

Best-coverage assays to detect the highest number of transcript variants possible, with gold-standard specificity, sensitivity, and reproducibility.

Discover more

Gene knockdown using siRNAs

Potent and specific siRNAs covering the druggable genome, with a proprietary algorithm and chemical modifications.

Discover more

Gene knockout using CRISPR-Cas9

Advanced gRNA designs for maximum efficiency without sacrificing specificity; arrayed libraries in flexible formats for a wide variety of assays.

Discover more

Protein analysis

Mass spectrometry


Understand the functions of individual proteins and their place in complex biological systems with state-of-the-art proteomics mass spectrometry.

Discover more

Protein–protein interaction assays


Characterize protein interactions through methods such as immunoprecipitation, yeast two-hybrid screening, phage display, and more.

Discover more

Protein structure analysis by cryo-electron microscopy

Generate complete structural information, uncover how targets interact with screening compounds.
 

Discover more

Immunoassays

Investigate protein and RNA biomarkers in key disease research areas from single-analyte analysis using ELISA formats to multiplex bead-based assays.

Discover more

Kinase assays

Create and validate an assay that meets your drug discovery or screening needs and fits your workflow.

Discover more

Nuclear magnetic resonance (NMR)

Extract useful chemical information for verification studies, characterize new compounds and monitor reactions with compact, affordable spectrometers.

Discover more

Cell-based analysis

Cell function assays

A broad range of cell function and behaviour assays and reagents that can be used on multiple instrument platforms.


Discover more

High-content screening analysis

Exceptional resolution with subcellular, automated detection and phenotyping with intact, fixed, or live cells.


Discover more

Cell analysis by flow cytometry

Flow cytometry instruments, assays, reagents, and antibodies to simultaneously analyze multiple proteins, gene expression, and cell functions.

Discover more

pH measurements

Make your pH measurements of your media, buffers, and reagents fast and reliable with meters, electrodes, and accessories designed to work seamlessly together.

Discover more

Assay development and screening Assay development and screening

Identify active compounds that interact with the selected target and/or modulate its activity via primary screening—i.e., hit identification. During secondary screening, evaluate and confirm initial hits with a different set of assays—i.e., hit validation.

Featured products

Cells and screening compound libraries

Cell model creation

Closely mimic the in vivo state and generate more physiologically relevant data with complete cell culture systems for drug discovery.

Discover more

Screening compound libraries

The Maybridge screening collection, a diverse set of >53,000 hit-like and lead-like molecules produced by synthetic techniques for screening campaigns.

Discover more

Automated reagent dispensing

Increase throughput, reproducibility, and speed through automated reagent dispensing into a wide selection of plate and volume ranges.

Discover more

Functional analysis

Target-based assays

Investigate the major druggable target classes: kinases, GPCRs, nuclear receptors, and ion channels.

Discover more

Pathway biology

Analyze complex signal transduction pathways in record time in live cells.

Discover more

Epigenetic tools

Investigate epigenetic enzymes and substrate modifications using cellular and biochemical assays.

Discover more

Reporter gene assays

Characterize gene regulatory sequences, transcription factor activity, cell signaling, and signaling pathways.

Discover more

Cell function assays

Cell-based assays and reagents for key cellular processes, including apoptosis, cell proliferation, cell cycle and viability.

Discover more

High-content screening

Platforms and software for cutting-edge images and high content imaging data in no time; exceptional resolution with subcellular, automated detection.

Discover more

Biodistribution assays


A range of products for imaging biological processes in live animals to understand cellular activity, effects of drugs, and disease progression.

Discover more

Protein structure analysis by cryo-electron microscopy

Generate complete structural information, uncover targets interact with screening compounds.
 

Discover more

Screening and profiling


Services with strict quality controls and automated processes driven by integrated informatics systems to help ensure reliable data is delivered every time.

Discover more

Robotics and lab automation

Comprehensive portfolio of laboratory automation solutions to improve processes and increase efficiency while generating accurate, reliable results.

Discover more

CO2 incubators

Achieve your goals faster, more reliably and with less effort, with our technology advancements in contamination control and uniform growth conditions.

Discover more

Biological safety cabinets

Maximize sample protection and user safety, with an emphasis on containment, comfort and convenience, all day, every day.

Discover more

Lead optimization and toxicology Lead optimization and toxicology

During lead optimization (LO), lead compounds are synthesized and modified to produce new analogs with improved potency and reduced off-target effects and tested to determine metabolic and safety profiles. Lead candidates are also tested for metabolic and safety profiles using ADME/Tox assays.

Featured products

Hit-to-lead building blocks

Unparalleled, off-the-shelf collection of building blocks with medicinally important ring systems, many which are unique to the Maybridge collection.

Discover more

Custom organic synthesis

ISO 9001:2000–certified facility, with experience in performing both small-scale and large-scale, milligram to kilogram, custom synthesis projects.

Discover more

ADME/Tox products

High-grade hepatic systems (cells, media, supplements and matrices), backed by extensive expertise and decades of experience.

Discover more

Target-based ADME/Tox assays

Determine the metabolic and safety profiles of lead candidates on a high-throughput scale.
 


Discover more

Cold storage equipments

Ultra-low freezers, high-performance refrigerators and freezers are designed with features that support sustainability objectives without compromising performance.

Discover more

Target Identification MethodsTarget discovery

Target-based drug discovery identifies a new therapeutic target, then screens for a drug that binds to it. Target deconvolution begins with a drug that is efficacious in phenotypic studies and retrospectively identifies the target.

Featured products

Genetic analysis

Sequencing solutions


Wide range of sequencing solutions from gold-standard Sanger sequencing technology, to flexible and scalable next-generation sequencing (NGS) products.

Discover more

NGS library preparation kits for Illumina platforms

Generate libraries more quickly, with less bias, in order to match the speed and capacity of Illumina instruments.
 

Discover more

Gene expression analysis using RNA sequencing

From targeted gene expression analysis to whole transcriptome sequencing, combine simple sample preparation and intuitive data analysis.

Discover more

Gene expression analysis using qPCR

Best-coverage assays to detect the highest number of transcript variants possible, with gold-standard specificity, sensitivity, and reproducibility.

Discover more

Gene knockdown using siRNAs

Potent and specific siRNAs covering the druggable genome, with a proprietary algorithm and chemical modifications.

Discover more

Gene knockout using CRISPR-Cas9

Advanced gRNA designs for maximum efficiency without sacrificing specificity; arrayed libraries in flexible formats for a wide variety of assays.

Discover more

Protein analysis

Mass spectrometry


Understand the functions of individual proteins and their place in complex biological systems with state-of-the-art proteomics mass spectrometry.

Discover more

Protein–protein interaction assays


Characterize protein interactions through methods such as immunoprecipitation, yeast two-hybrid screening, phage display, and more.

Discover more

Protein structure analysis by cryo-electron microscopy

Generate complete structural information, uncover how targets interact with screening compounds.
 

Discover more

Immunoassays

Investigate protein and RNA biomarkers in key disease research areas from single-analyte analysis using ELISA formats to multiplex bead-based assays.

Discover more

Kinase assays

Create and validate an assay that meets your drug discovery or screening needs and fits your workflow.

Discover more

Nuclear magnetic resonance (NMR)

Extract useful chemical information for verification studies, characterize new compounds and monitor reactions with compact, affordable spectrometers.

Discover more

Cell-based analysis

Cell function assays

A broad range of cell function and behaviour assays and reagents that can be used on multiple instrument platforms.


Discover more

High-content screening analysis

Exceptional resolution with subcellular, automated detection and phenotyping with intact, fixed, or live cells.


Discover more

Cell analysis by flow cytometry

Flow cytometry instruments, assays, reagents, and antibodies to simultaneously analyze multiple proteins, gene expression, and cell functions.

Discover more

pH measurements

Make your pH measurements of your media, buffers, and reagents fast and reliable with meters, electrodes, and accessories designed to work seamlessly together.

Discover more

Assay development and screening Assay development and screening

Identify active compounds that interact with the selected target and/or modulate its activity via primary screening—i.e., hit identification. During secondary screening, evaluate and confirm initial hits with a different set of assays—i.e., hit validation.

Featured products

Cells and screening compound libraries

Cell model creation

Closely mimic the in vivo state and generate more physiologically relevant data with complete cell culture systems for drug discovery.

Discover more

Screening compound libraries

The Maybridge screening collection, a diverse set of >53,000 hit-like and lead-like molecules produced by synthetic techniques for screening campaigns.

Discover more

Automated reagent dispensing

Increase throughput, reproducibility, and speed through automated reagent dispensing into a wide selection of plate and volume ranges.

Discover more

Functional analysis

Target-based assays

Investigate the major druggable target classes: kinases, GPCRs, nuclear receptors, and ion channels.

Discover more

Pathway biology

Analyze complex signal transduction pathways in record time in live cells.

Discover more

Epigenetic tools

Investigate epigenetic enzymes and substrate modifications using cellular and biochemical assays.

Discover more

Reporter gene assays

Characterize gene regulatory sequences, transcription factor activity, cell signaling, and signaling pathways.

Discover more

Cell function assays

Cell-based assays and reagents for key cellular processes, including apoptosis, cell proliferation, cell cycle and viability.

Discover more

High-content screening

Platforms and software for cutting-edge images and high content imaging data in no time; exceptional resolution with subcellular, automated detection.

Discover more

Biodistribution assays


A range of products for imaging biological processes in live animals to understand cellular activity, effects of drugs, and disease progression.

Discover more

Protein structure analysis by cryo-electron microscopy

Generate complete structural information, uncover targets interact with screening compounds.
 

Discover more

Screening and profiling


Services with strict quality controls and automated processes driven by integrated informatics systems to help ensure reliable data is delivered every time.

Discover more

Robotics and lab automation

Comprehensive portfolio of laboratory automation solutions to improve processes and increase efficiency while generating accurate, reliable results.

Discover more

CO2 incubators

Achieve your goals faster, more reliably and with less effort, with our technology advancements in contamination control and uniform growth conditions.

Discover more

Biological safety cabinets

Maximize sample protection and user safety, with an emphasis on containment, comfort and convenience, all day, every day.

Discover more

Lead optimization and toxicology Lead optimization and toxicology

During lead optimization (LO), lead compounds are synthesized and modified to produce new analogs with improved potency and reduced off-target effects and tested to determine metabolic and safety profiles. Lead candidates are also tested for metabolic and safety profiles using ADME/Tox assays.

Featured products

Hit-to-lead building blocks

Unparalleled, off-the-shelf collection of building blocks with medicinally important ring systems, many which are unique to the Maybridge collection.

Discover more

Custom organic synthesis

ISO 9001:2000–certified facility, with experience in performing both small-scale and large-scale, milligram to kilogram, custom synthesis projects.

Discover more

ADME/Tox products

High-grade hepatic systems (cells, media, supplements and matrices), backed by extensive expertise and decades of experience.

Discover more

Target-based ADME/Tox assays

Determine the metabolic and safety profiles of lead candidates on a high-throughput scale.
 


Discover more

Cold storage equipments

Ultra-low freezers, high-performance refrigerators and freezers are designed with features that support sustainability objectives without compromising performance.

Discover more

Solutions to enable a robust biotech commercialization strategy

 

Style Sheet for Global Design System