Solvents are substances, mostly in the form of liquid, which can dissolve a solute and form a solution. Solvents can be broadly classified into two types—polar solvents (e.g., water) and non-polar solvents (e.g., hexane)—based on their dielectric constant.
Polar solvents have a strong dielectric constant. They have one or more electronegative atoms and can be further classified into two sub-groups: protic solvents, which solvate anions through hydrogen bonds (e.g., water, methanol, ethanol), and aprotic solvents, which solvate cations through dipole induced interactions (e.g., DMSO, DMF, acetone). Common functional groups present in polar solvents include ahydroxyl, carbonyl, carboxyl, and amido.
Non-polar solvents contain bonds between atoms such as carbon and hydrogen that have similar electronegativities and thus, lack partial charges. Examples include alkanes (pentane, hexane, and heptane) and aromatics (benzene, toluene, and xylene). Other common nonpolar solvents include chloroform, diethyl ether, ethyl acetate, methylene chloride, and pyridine.
Thermo Scientific offers a wide selection of solvents, available in multiple grades and purity levels, for your chromatography (LC, LC/MS, GC, protein purification), life sciences, organic synthesis, and general laboratory workflows and applications.
Find exactly what you need from our portfolio of more than 800 high-purity solvents formulated to suit applications for LC/MS, HPLC, UHPLC/MS, gas chromatography, spectrometry, and more. Our solvents are manufactured in ISO 9001-certified facilities and undergo quality assurance testing designed to bring you the lot-to-lot and bottle-to-bottle consistency you rely on.
In this webinar, learn about the different grades of reagents, recommendations for their use based on application, and materials and processes to clean and maintain your instruments.
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