Solvents are substances, mostly in the form of liquid, which can dissolve a solute and form a solution. Solvents can be broadly classified into two types—polar solvents (e.g., water) and non-polar solvents (e.g., hexane)—based on their dielectric constant.

Polar solvents have a strong dielectric constant. They have one or more electronegative atoms and can be further classified into two sub-groups: protic solvents, which solvate anions through hydrogen bonds (e.g., water, methanol, ethanol), and aprotic solvents, which solvate cations through dipole induced interactions (e.g., DMSO, DMF, acetone). Common functional groups present in polar solvents include ahydroxyl, carbonyl, carboxyl, and amido.

Non-polar solvents contain bonds between atoms such as carbon and hydrogen that have similar electronegativities and thus, lack partial charges. Examples include alkanes (pentane, hexane, and heptane) and aromatics (benzene, toluene, and xylene). Other common nonpolar solvents include chloroform, diethyl ether, ethyl acetate, methylene chloride, and pyridine.

Thermo Scientific offers a wide selection of solvents, available in multiple grades and purity levels, for your chromatography (LC, LC/MS, GC, protein purification), life sciences, organic synthesis, and general laboratory workflows and applications.

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Analytical Grade Solvents

Our high-quality analytical grade solvents, manufactured under stringent ACS quality control parameters, are suitable for research and quality control laboratories.

Chromatography Solvents

Our chromatography solvents are intended for use in research applications including LC, LC/MS, GC, protein purification, and more.

Essential Solvents

Our essential solvents are suitable for research, development, and laboratory applications and are available in several formulations and packaging options.

Life Science Solvents

Our high-purity life science solvents are suitable for use in many research applications including cytology and histology, cell culture, molecular biology, and sequencing.

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Solvents Application Guide

Solvents Application Guide

Find exactly what you need from our portfolio of more than 800 high-purity solvents formulated to suit applications for LC/MS, HPLC, UHPLC/MS, gas chromatography, spectrometry, and more. Our solvents are manufactured in ISO 9001-certified facilities and undergo quality assurance testing designed to bring you the lot-to-lot and bottle-to-bottle consistency you rely on.

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Webinar: Selecting the Right Solvents for Your Separations

In this webinar, learn about the different grades of reagents, recommendations for their use based on application, and materials and processes to clean and maintain your instruments.

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