Cryo-electron microscopy (cryo-EM) is a powerful technique for the fundamental study of viral function and infectivity as its visualization scale and resolution are ideally suited for analysis of the entire viral capsid.
One of the first 3D structures to be unraveled via cryo EM (single particle analysis) was a virus because their stable and symmetrical shape make them an ideal choice for cryo-EM method development, which benefits from structural symmetry. Thanks to cryo electron microscopy, clearer insights have been gained into the morphology and assembly strategy of viruses. In addition, cryo-EM plays a crucial role in the development of more efficient vaccines as it provides information on the specific binding properties of the antigen-antibody interface.
While single particle analysis was the method of choice for viral structural analysis, cellular cryo tomography has provided further insights into the viral replication, assembly, and maturation processes, granting an even broader perspective on viral-induced disease mechanisms.
Drug Discovery
Learn how to take advantage of rational drug design for many more major drug target classes, leading to best-in-class drugs.
Infectious Disease Research
Cryo-EM techniques enable multiscale observations of 3D biological structures in their near-native states, informing faster, more efficient development of therapeutics.
Structural Biology Research
Cryo-electron microscopy enables the structural analysis of challenging biological targets such as large complexes, flexible species and membrane protein.
Pathology Research
Transmission electron microscopy (TEM) is used when the nature of the disease cannot be established via alternative methods. With nano-biological imaging, TEM provides accurate and reliable insight for certain pathologies.
Single Particle Analysis
Single particle analysis (SPA) is a cryo electron microscopy technique that enables structural characterization at near-atomic resolutions, unraveling dynamic biological processes and the structure of biomolecular complexes/assemblies.
Cryo-Tomography
Cryo electron tomography (cryo-ET) delivers both structural information about individual proteins as well as their spatial arrangements within the cell. This makes it a truly unique technique and also explains why the method has such an enormous potential for cell biology. Cryo-ET can bridge the gap between light microscopy and near-atomic-resolution techniques like single-particle analysis.
Single Particle Analysis
Single particle analysis (SPA) is a cryo electron microscopy technique that enables structural characterization at near-atomic resolutions, unraveling dynamic biological processes and the structure of biomolecular complexes/assemblies.
Cryo-Tomography
Cryo electron tomography (cryo-ET) delivers both structural information about individual proteins as well as their spatial arrangements within the cell. This makes it a truly unique technique and also explains why the method has such an enormous potential for cell biology. Cryo-ET can bridge the gap between light microscopy and near-atomic-resolution techniques like single-particle analysis.
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