Scientific review: Using structural biology to gain a deeper understanding of HIV
Cryo-EM has become a routine technology for determining the three-dimensional structure of biological macromolecules to understand their activities and interactions as the molecular basis of life’s processes. Structure is the key to understanding function. Recent structural biology developments that have been made possible by cryo-electron microscopy (cryo-EM) have enabled researchers to better understand complex biological molecules with unprecedented ease and efficiency. These complex molecules were previously unattainable through traditional methods of XRD and NMR.
These developments have tremendous implications for the field of HIV research. Cryo-EM have provided deeper insights into all facets of HIV research, ranging from anti-viral drug development to vaccine development approaches.
We have curated an overview of recent scientific publications on how cryo-EM methods have been advancing HIV vaccine development and structure-based drug design research.
These studies used state-of-the-art cryo-EM workflows from Thermo Fisher Scientific. These workflows are built around our fully automated cryo-electron microscopes designed for rapid, stable, and high-resolution data collection on frozen-hydrated samples: Thermo Scientific Talos Arctica Cryo-TEM and Thermo Scientific Krios Cryo-TEM. Learn more about our cryo-EM workflow solutions.