HPLC and UHPLC Systems

Excellence built into each innovative LC system

Separate even the most complex samples with confidence. With an extensive portfolio of innovative Thermo Scientific HPLC and UHPLC systems, you can choose the best system for your application. Learn which system is right for you, and customize it to meet your separation needs.

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Browse our complete portfolio below, or let one of our experts help you tailor a selection specific to your application and workflow needs.

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Reliable, flexible, and robust chromatography with unmatched performance

Whether you need a high-end 1500 bar system or are looking for a simple-to-use nanoLC, learn how our innovative Thermo Scientific Vanquish UHPLC platform, our proven UltiMate 3000 systems, and our sensitive nano-, capillary-, and micro-flow rate systems can help you separate your science from the status quo.

Regardless of which system configuration you choose, you will receive a highly integrated setup with optimized fluidic connections. All of our HPLC and UHPLC systems have multiple detector options, and use our Thermo Scientific Viper Fingertight connections. Viper fittings are easy to install, completely tool free, virtually zero-dead volume connections that hold up to 1500 bar/22,000 psi.

Additionally, you can streamline your lab with our easy-to-use Thermo Scientific Chromeleon Chromatography Data System (CDS) software. Chromeleon CDS is the preferred software for single-point intelligent control, unique data processing tools, and intelligent run automation functionality. We also offer integration solutions for other CDS packages.

HPLC and UHPLC systems categories

Experience uncompromised UHPLC without compromising performance, robustness or ease of use. These systems are the most versatile and flexible systems that can handle any application. The Vanquish platform is equipped with unique Thermo Scientific SmartFlow and SmartInject technology, ensuring precision metering, gradient accuracy, and retention time and peak area reproducibility. Vanquish systems push chromatographic boundaries, and separate your toughest analytical challenges with confidence.

Are your sample volumes limited but require high sensitivity? Choose our high throughput solutions for applications such as LC-MS proteomics, metabolomics, or intact protein analysis. Achieve effortless nano-flow with our fully integrated Thermo Scientific EASY-nLC 1200, or leverage the flexibility of nano-, capillary-, and micro-flow rates with the customizable UltiMate 3000 RSLCnano system.  Both systems integrate seamlessly with Thermo Scientific mass spectrometers.

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Featured HPLC and UHPLC systems video
HPLC and UHPLC basics

Learn about the history and basics of HPLC and UHPLC.