HPLC and UHPLC Systems

Excellence built into each innovative liquid chromatography system

Separate even the most complex samples with confidence. With an extensive portfolio of innovative Thermo Scientific HPLC and UHPLC systems, you can choose the best system for your application. Learn which system is right for you and customize it to meet your separation needs.

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Browse our complete portfolio below, or let one of our experts help you tailor a selection specific to your application and workflow needs.

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Reliable, flexible, and robust chromatography with unmatched performance

Whether you need a high-end 1500 bar system or are looking for a simple-to-use nanoLC, learn how the innovative and proven Thermo Scientific Vanquish HPLC and UHPLC systems, the established UltiMate 3000 systems, and the sensitive nano-, capillary-, and micro-flow rate systems can help you separate your science from the status quo.

Regardless of which system configuration you choose, you will receive a highly integrated setup with optimized fluidic connections. All of these HPLC and UHPLC systems have multiple detector options and use Thermo Scientific Viper finger-tight connections. Viper fittings are easy to install, completely tool-free, virtually zero-dead volume connections that hold up to 1500 bar.

Additionally, you can streamline your lab with our easy-to-use Thermo Scientific Chromeleon Chromatography Data System (CDS) software. Chromeleon CDS is the preferred software for single-point intelligent control, unique data processing tools, and intelligent run-automation functionality. We also offer integration solutions for other CDS packages.


HPLC and UHPLC systems categories

Vanquish HPLC and UHPLC Systems

With innovative technology and fine detail, Thermo Scientific Vanquish HPLC and UHPLC systems are the most advanced HPLC and UHPLC instruments available today. The Vanquish platform delivers maximized resolution, throughput, repeatability, and productivity while maintaining impeccable quality, robustness, and simplicity. It provides you with everything you need to solve your toughest analytical challenges with confidence.

UltiMate 3000 HPLC and UHPLC Systems

Achieve reliability in results while meeting the needs and requirements for your application with Thermo Scientific UltiMate 3000 HPLC systems. By allowing customizable configurations, these systems provide you with the flexibility to succeed in your analyses.

Nano-, capillary-, and micro-flow UHPLC Systems

Are your sample volumes limited but you require high sensitivity? Choose our high-throughput solutions for applications such as LC-MS proteomics, metabolomics, or intact protein analysis. Achieve effortless nano-flow with our fully integrated Thermo Scientific EASY-nLC 1200, or leverage the flexibility of nano-, capillary-, and micro-flow rates with the customizable UltiMate 3000 RSLCnano System.  Both systems integrate seamlessly with Thermo Scientific mass spectrometers.

Transcend UHPLC Systems

Boost your LC-MS throughput with Transcend UHPLC Systems. The combination of up to four liquid chromatography channels maximizes mass spectrometer utilization and reduces idleness to a minimum. Optional TurboFlow technology automates sample preparation for fastest time to results. The Transcend UHPLC systems are controlled by Aria software for easy method setup and intelligent analysis scheduling.


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New! Introducing LC-MS Medical Devices for In Vitro Diagnostic Use

New! Introducing LC-MS Medical Devices for In Vitro Diagnostic Use

The new portfolio of Thermo Scientific LC-MS Medical Devices for laboratory developed tests offers the clinical laboratory six unique choices that meet a wide range of throughput and sensitivity needs.


Monitor your system remotely from anywhere in the world
  • Connect your lab to boost productivity with secure remote access to your data and instruments
  • Real-time monitoring of your instrument with automatic email notifications
  • Store data in secure accounts and share with colleagues and collaborators

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Featured HPLC and UHPLC systems video

LC Columns and Consumables Catalog
LC consumables catalog

Access the latest version of our Chromatography Consumables Catalog to ensure that you're optimizing your applications! Our enhanced online version features a robust applications search tool, access to method development guides, application notebooks, and much more.

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