|Organism Type||Hamster||CHO-Lec2 cells are mutants that have a 70–90% de- ficiency of sialic acid in their glycoproteins and gangliosides. Transport of CMP-sialic acid into the Golgi vesicles of these cells was 90% defective compared to vesicles from wild-type cells, whereas transport of other nucleotide sugars was normal. These cells do not have a defect in biosynthesis of CMP-sialic acid, asialoglycoproteins, and asialoglycosphingolipids, and they have normal levels of sialyltransferases.|
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