Interleukin 27, or IL-27 is a cytokine belonging to the IL-12 family. It is a heterodimeric cytokine composed of EBI3 and p28 subunits. IL-27 is produced by activated dendritic cells and macrophages in response to Toll-like receptor ligands and pro-inflammatory cytokines. IL-27 promotes CD4+ T cell differentiation to the Th1 lineage by inducing expression of the transcription factor T-bet and up regulating IL-12R beta2, which in turn suppresses Th2 and Th17 differentiation and proliferation. In humans, the gene is located on the p arm of chromosome 16.
IL-27 p28 subunit; IL-27 subunit alpha; IL-27-A; IL-27A; IL27-A; IL27A; IL27p28; IL30; interleukin 30; Interleukin-27 subunit alpha; Interleukin-30; p28
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