Tumor Necrosis Factor-Alpha (TNF alpha) is a protein secreted by lipopolysaccharide-stimulated macrophages, and causes tumor necrosis when injected into tumor-bearing mice. TNF alpha is believed to mediate pathogenic shock and tissue injury associated with endotoxemia. TNF alpha exists as a multimer of two, three, or five noncovalently linked units, but shows a single ~17 kDa band following SDS-PAGE under non-reducing conditions.
APC1 protein; Cachectin; DADB-70P7.1; DIF; TNF, macrophage-derived; TNF, monocyte-derived; TNF-a; TNF-alpha; TNFA; TNFSF2; Tumor necrosis factor; tumor necrosis factor ligand 1F; Tumor necrosis factor ligand superfamily member 2; tumor necrosis factor-alpha
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