The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This protein localizes to nuclear bodies. Its structure is similar to some tumor suppressor proteins and its gene maps to a locus thought to contain tumor suppressor genes.
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E3 ubiquitin-protein ligase TRIM8; GERP; glioblastoma expressed ring finger protein; Glioblastoma-expressed RING finger protein; probable E3 ubiquitin-protein ligase TRIM8; RING finger protein 27; RING-type E3 ubiquitin transferase TRIM8; RNF27; tripartite motif protein TRIM8; tripartite motif-containing 8; Tripartite motif-containing protein 8