Antibodies that detect ATG12 can be used in several scientific applications, including Western Blot, Immunocytochemistry, Immunohistochemistry (Paraffin), Immunohistochemistry and Immunoprecipitation. These antibodies target ATG12 in Human, Mouse, Rat, Yeast and Drosophila samples. Our ATG12 polyclonal, monoclonal, recombinant monoclonal and recombinant polyclonal antibodies are developed in Rabbit and Mouse. These antibodies have been verified by Cell treatment and Knockdown to confirm specificity to ATG12. Find the ATG12 antibody that fits your needs. Choose from 1 of 19 ATG12 antibodies, which have been validated in experiments with 21 publications and 48 images featured in our data gallery.
Browse primary antibodies for WB, Flow, IHC, ICC/IF, ELISA, IP, and other applications. Antibodies with Advanced Verification data have been validated for specificity to ensure that the antibody binds to the antigen stated. If you cannot find the antibody you re looking for, contact us today to develop custom antibodies for specific targets, species and applications.
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ATG12, a member of the autophagy protein family, forms a conjugate with ATG5; this conjugate has a ubiquitin-protein ligase (E3)-like activity for protein lipidation in autophagy. This conjugate also associates with innate immune response proteins such as RIG-I and VISA (also known as IPS-1), inhibiting type I interferon production and permitting viral replication in host cells. ATG12 has also been shown to interact with ATG10 in human embryonic kidney cells in the presence of ATG7. At least two isoforms of ATG12 are known to exist. Autophagy, the process of bulk degradation of cellular proteins through an autophagosomic-lysosomal pathway is important for normal growth control and may be defective in tumor cells. It is involved in the preservation of cellular nutrients under starvation conditions as well as the normal turnover of cytosolic components. This process is negatively regulated by TOR (Target of rapamycin) through phosphorylation of autophagy protein APG1.
APG 12; Apg12 (autophagy, yeast) homolog; APG12-like; ATG12 autophagy related 12 homolog; autophagy-related 12; Autophagy-related protein 12; OTTHUMP00000159129; Ubiquitin-like protein ATG12
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