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CD119 (IFN gamma Receptor 1) Monoclonal Antibody (GIR-208 (GIR 208)), Biotin, eBioscience™
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FIGURE: 1 / 7
CD119 (IFN gamma Receptor 1) Antibody (13-1199-82) in Flow
Staining of normal human peripheral blood cells with 0.125 µg of Mouse IgG1 K Isotype Control Biotin (Product # 13-4714-85) (blue histogram) or 0.125 µg of Anti-Human CD119 (IFN gamma Receptor 1) Biotin (purple histogram) followed by Streptavidin PE (Product # 12-4317-87). Cells in the monocyte gate were used for analysis.
Product Details
13-1199-82
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG1
Recommended Isotype Control
Class
Monoclonal
Type
Antibody
Clone
GIR-208 (GIR 208)
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Amount
100 µg
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.2
Contains
0.09% sodium azide
Storage conditions
4°C, store in dark, DO NOT FREEZE!
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Description: The monoclonal antibody reacts with human CD119 also known as the IFN gamma receptor 1 (alpha chain). IFN gamma R1 is found in a complex with IFN gamma receptor beta and recognizes with high affinity IFN gamma. Expression is ubiquitous but low, although some cell types, such as monocytes express higher levels.
The GIR-208 monoclonal antibody is blocked from binding when IFN gamma is bound to the receptor.
Applications Reported: This GIR-208 (GIR 208) antibody has been reported for use in flow cytometric analysis.
Applications Tested: This GIR-208 (GIR 208) antibody has been tested by flow cytometric analysis of normal human peripheral blood cells. This can be used at less than or equal to 0.25 µg per test. A test is defined as the amount (µg) of antibody that will stain a cell sample in a final volume of 100 µL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test. It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest.
Filtration: 0.2 µm post-manufacturing filtered.
Target Information
This gene (IFNGR1) encodes the ligand-binding chain (alpha) of the gamma interferon receptor. Human interferon-gamma receptor is a heterodimer of IFNGR1 and IFNGR2. A genetic variation in IFNGR1 is associated with susceptibility to Helicobacter pylori infection. In addition, defects in IFNGR1 are a cause of mendelian susceptibility to mycobacterial disease, also known as familial disseminated atypical mycobacterial infection.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: antiviral protein, type 2; AVP, type 2; CD119; CD119 antigen; CDw119; cytokine receptor; IFN-gamma receptor 1; IFN-gamma-R-alpha; IFN-gamma-R1; IFNgR1; immune interferon receptor 1; Interferon gamma receptor 1; Interferon gamma receptor alpha-chain; interferon-gamma receptor; interferon-gamma receptor alpha chain; unnamed protein product
Gene Aliases: CD119; IFNGR; IFNGR1; IMD27A; IMD27B
UniProt ID: (Human) P15260
Entrez Gene ID: (Human) 3459
microglial cell activation
immune system process
signal transduction
JAK-STAT cascade
response to virus
positive regulation of gene expression
cytokine-mediated signaling pathway
positive regulation of tumor necrosis factor production
type III interferon-mediated signaling pathway
astrocyte activation
defense response to virus
interferon-gamma-mediated signaling pathway
defense response to other organism
cellular response to virus
negative regulation of beta-amyloid clearance
positive regulation of beta-amyloid formation
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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