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NeoBiotechnologies

HER-2/c-erbB-2/neu/CD340 Monoclonal Antibody (HRB2/258), CF® 488

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Product Details

2064-MSM2-CF488-100T

Applications
Tested Dilution
Publications

Immunocytochemistry (ICC/IF)

1:50-1:100
-

Flow Cytometry (Flow)

5 µL/10^6 cells
-
Product Specifications

Species Reactivity

Human, Rat

Host/Isotype

Mouse / IgG2a, kappa

Class

Monoclonal

Type

Antibody

Clone

HRB2/258

Immunogen

Recombinant extracellular domain of human HER-2 protein

Conjugate

CF® 488 CF® 488 CF® 488

Excitation/Emission Max

488/515 nm

Form

Liquid

Concentration

100 µg/mL

Amount

50 µg

Purification

Protein A/G

Storage buffer

PBS, pH 7.4, with 0.05% BSA

Contains

0.05% sodium azide

Storage conditions

4°C, store in dark, DO NOT FREEZE!

Shipping conditions

Ambient (domestic); Wet ice (international)

Target Information

ErbB2 (HER2) is a receptor tyrosine kinase that is overexpressed in some breast tumors. Herceptin, used in treatment of metastatic Her2-positive cancer, is monoclonal antibody targeting this kinase.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: approximately 68 kDa secreted autoinhibitor glycoprotein; Avian erythroblastosis viral (v-erb-B2) oncogene homologue 2 (neuro/glioblastoma derived oncogene homolog); c-erb B2/neu protein; C-erbB-2; CD antigen CD340; CD340; epidermal growth factor receptor-related protein; erb-b2; erbb 2; ErbB2 (pTyr1139); ErbB2 (pY1139); ErbB2 phospho Y1139; her 2; HER2 receptor; HER2/neu receptor; herstatin; human epidermal growth factor receptor 2; metas; Metastatic lymph node gene 19 protein; MLN 19; NEU proto-oncogene; neuro/glioblastoma derived oncogene homolog; neuroblastoma/glioblastoma derived oncogene homolog; p185erbB2; p185neu; phospho ErbB2; Proto-oncogene c-ErbB-2; Proto-oncogene Neu; Receptor tyrosine-protein kinase erbB-2; Tyrosine kinase-type cell surface receptor HER2; unnamed protein product; v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2; v-erb-b2 avian erythroblastic leukemia viral oncoprotein 2; v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog

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Gene Aliases: c-ERB-2; c-ERB2; CD340; ERBB2; HER-2; HER-2/neu; HER2; MLN 19; MLN-19; MLN19; NEU; NGL; p185(erbB2); TKR1; VSCN2

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UniProt ID: (Human) P04626

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Entrez Gene ID: (Human) 2064, (Rat) 24337

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Function(s)
nucleotide binding RNA polymerase I core binding protein kinase activity protein tyrosine kinase activity transmembrane receptor protein tyrosine kinase activity transmembrane signaling receptor activity receptor binding protein binding ATP binding coreceptor activity kinase activity transferase activity growth factor binding receptor tyrosine kinase binding identical protein binding ErbB-3 class receptor binding protein heterodimerization activity glycoprotein binding DNA binding receptor signaling protein tyrosine kinase activity protein C-terminus binding protein phosphatase binding ubiquitin protein ligase binding Hsp90 protein binding transmembrane signal receptor
Process(es)
protein phosphorylation signal transduction cell surface receptor signaling pathway enzyme linked receptor protein signaling pathway transmembrane receptor protein tyrosine kinase signaling pathway epidermal growth factor receptor signaling pathway nervous system development peripheral nervous system development heart development neuromuscular junction development motor neuron axon guidance cell proliferation positive regulation of gene expression Schwann cell development peptidyl-tyrosine phosphorylation neuron differentiation positive regulation of cell growth regulation of microtubule-based process immature T cell proliferation in thymus negative regulation of immature T cell proliferation in thymus positive regulation of Rho protein signal transduction intracellular signal transduction ERBB2 signaling pathway ERBB2-ERBB3 signaling pathway ERBB2-EGFR signaling pathway ERBB2-ERBB4 signaling pathway wound healing regulation of cell proliferation myelination negative regulation of apoptotic process positive regulation of MAP kinase activity positive regulation of MAPK cascade protein kinase B signaling positive regulation of translation regulation of angiogenesis positive regulation of cell adhesion positive regulation of transcription from RNA polymerase I promoter oligodendrocyte differentiation positive regulation of epithelial cell proliferation regulation of ERK1 and ERK2 cascade cellular response to growth factor stimulus cellular response to epidermal growth factor stimulus semaphorin-plexin signaling pathway positive regulation of protein targeting to membrane neurotransmitter receptor localization to postsynaptic specialization membrane positive regulation of intracellular signal transduction liver development positive regulation of protein phosphorylation transcription, DNA-templated central nervous system development skeletal muscle tissue development positive regulation of cell proliferation glial cell differentiation phosphatidylinositol 3-kinase signaling positive regulation of phosphatidylinositol 3-kinase signaling signal transduction by protein phosphorylation response to progesterone response to drug tongue development estrous cycle regulation of cell differentiation positive regulation of transcription from RNA polymerase III promoter positive regulation of Ras protein signal transduction protein autophosphorylation sympathetic nervous system development response to axon injury mammary gland involution
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