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Invitrogen
P-cadherin Monoclonal Antibody (12H6)
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FIGURE: 1 / 7
P-cadherin Antibody (32-4000) in IHC (F)
Immunohistochemistry analysis of P-Cadherin was performed on cryosections of human skin tissue. Tissues were blocked in 10% normal goat serum in 1X PBS containing 0.1% Triton X-100 (1X PBS-T) for 1 hour at room temperature (RT). The tissues were labeled with a P-Cadherin monoclonal antibody (clone 12H6, red, Product # 32-4000) diluted 1:50 in 3% normal goat serum in 1X PBS-T for 1 hour at RT, followed by de... View More
Product Details
32-4000
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Dog,
Human
Published species
Human
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
12H6
Immunogen
Human P-Cadherin fusion protein.
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Amount
100 µg
Purification
Protein A
Storage buffer
PBS, pH 7.4
Contains
0.1% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
32-4000 has successfully been used in western blot to detect P-cadherin in MDCK cell lysates.
Target Information
P-cadherin, also known as Cadherin-3, is a Type 1 cadherin protein that belongs to the cadherin superfamily. Type 1 cadherins are single-pass transmembrane proteins that have 5 extracellular cadherin repeats and an intracellular domain that binds p120-catenin and beta-catenin. Cadherins are calcium-dependent cell-cell adhesion glycoproteins responsible for a range of processes including development, wound healing, cell-cell signaling, cell growth and differentiation. P-cadherin is expressed in human fetal structures, and in adult tissues such as the basal layer of the epidermis, breast, prostate, ovary, cervix, hair follicle, and corneal endothelium. P-cadherin expression has also been reported on embryonic stem cells, and stem cells of the normal mammary gland, and hair follicle. Overexpression of P-cadherin has been associated with poor prognosis in breast, prostate, ovary, colon, and stomach carcinomas. Mutations in CDH3 are associated with congential hypotrichosis with juvenile macular dystrophy.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: CADH3; cadherin 15, M-cadherin (myotubule); cadherin 3, type 1, P-cadherin (placental); Cadherin-3; calcium-dependent adhesion protein, placental; P-cadherin; Placental cadherin; Placental-cadherin; unnamed protein product
Gene Aliases: CDH3; CDHP; HJMD; PCAD
UniProt ID: (Human) P22223
Entrez Gene ID: (Dog) 611010, (Human) 1001
cell morphogenesis
retina homeostasis
cell-cell junction assembly
cell adhesion
homophilic cell adhesion via plasma membrane adhesion molecules
visual perception
positive regulation of gene expression
positive regulation of keratinocyte proliferation
calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules
cell migration
hair cycle process
negative regulation of transforming growth factor beta receptor signaling pathway
keratinization
positive regulation of monophenol monooxygenase activity
adherens junction organization
positive regulation of insulin-like growth factor receptor signaling pathway
cell-cell adhesion mediated by cadherin
positive regulation of melanin biosynthetic process
regulation of transport
negative regulation of catagen
positive regulation of canonical Wnt signaling pathway
cell-cell adhesion
positive regulation of melanosome transport
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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