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Invitrogen

Aurora A Monoclonal Antibody (35C1)

Advanced Verification
2 Published Figures
7 References
View all (37) Aurora A antibodies

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Aurora A Monoclonal Antibody (35C1)

Product Details

45-8900

Applications
Tested Dilution
Publications

Western Blot (WB)

1-3 µg/mL
View 5 publications 5 publications

Immunocytochemistry (ICC/IF)

1-2 µg/mL
View 1 publication 1 publication

Immunoprecipitation (IP)

5 µg
-

Miscellaneous PubMed (Misc)

-
View 1 publication 1 publication
Product Specifications

Species Reactivity

Bovine, Dog, Horse, Human, Mouse, Non-human primate, Pig, Rat

Published species

Hamster, Human, Mouse

Host/Isotype

Mouse / IgG1

Class

Monoclonal

Type

Antibody

Clone

35C1

Immunogen

Recombinant protein derived from the full length of human Aurora A Kinase protein
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.5 mg/mL

Amount

100 µg

Purification

Protein A

Storage buffer

PBS, pH 7.4

Contains

0.1% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2533839

Target Information

AURKA (Aurora A) is a serine/threonine kinase that regulates mitosis by association in vivo with centrosomes. Overexpression of AURKA is observed in many types of cancer. Aurora A plays a role in cell cycle regulation during anaphase and/or telophase, in relation to the function of the centrosome/spindle pole region during chromosome segregation. Aurora A plays a key role during tumor development and progression and is overexpressed in many human cancers including breast, ovarian and colorectal. Aurora A is viewed as a potential target for anticancer drug treatment. Tissue specificity: Highly expressed in testis and weakly in skeletal muscle, thymus and spleen.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Bioinformatics

Protein Aliases: ARK-1; AURAK; Aurora 2; aurora A; Aurora A Kinase; aurora family kinase 1; Aurora kinase A; Aurora-A; aurora-related kinase 1; aurora/IP; Aurora/IPL1-related kinase 1; AURORA2; Breast tumor-amplified kinase; EC 2.7.11.1; hARK1; Ipl1- and aurora-related kinase 1; IPL1-related kinase; MGC34538; OTTHUMP00000031341; OTTHUMP00000166072; ratAurA; RP5-1167H4.6; sereine threonine kinase; serine/threonine kinase 6; serine/threonine protein kinase 6; Serine/threonine-protein kinase 15; Serine/threonine-protein kinase 6; Serine/threonine-protein kinase aurora-A; Serine/threonine-protein kinase Ayk1

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Gene Aliases: AIK; AIRK1; ARK-1; ARK1; AU019385; AURA; AURKA; Aurora-A; AW539821; AYK1; BTAK; IAK; IAK1; STK15; STK6

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UniProt ID: (Dog) A0A8I3S724, (Bovine) Q2TA06, (Pig) A5GFW1, (Mouse) P97477

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Entrez Gene ID: (Dog) 485940, (Horse) 100050161, (Bovine) 504437, (Pig) 574063, (Mouse) 20878, (Rat) 261730

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Function(s)
protein kinase activity ATP binding protein kinase binding ubiquitin protein ligase binding protein heterodimerization activity nucleotide binding protein serine/threonine kinase activity protein serine/threonine/tyrosine kinase activity protein binding kinase activity transferase activity transferase activity, transferring phosphorus-containing groups histone serine kinase activity non-receptor serine/threonine protein kinase
Process(es)
spindle assembly involved in female meiosis I mitotic centrosome separation response to wounding anterior/posterior axis specification negative regulation of gene expression regulation of protein stability negative regulation of protein binding positive regulation of proteasomal ubiquitin-dependent protein catabolic process histone-serine phosphorylation negative regulation of apoptotic process cell division centrosome localization protein localization to centrosome liver regeneration positive regulation of oocyte maturation neuron projection extension meiotic spindle organization cell projection organization positive regulation of translation positive regulation of meiotic cell cycle process involved in oocyte maturation microtubule cytoskeleton organization mitotic cell cycle protein phosphorylation cell cycle spindle organization mitotic spindle organization mitotic nuclear division meiotic nuclear division phosphorylation regulation of cytokinesis centrosome organization negative regulation of spindle checkpoint response to estradiol
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