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Proteintech
BSAP/PAX5 Monoclonal Antibody (2H2D6)
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Product Details
60349-1-IG
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
2H2D6
Immunogen
BSAP,PAX5 Fusion Protein Ag16023 (145-392 aa encoded by BC156927)
Conjugate
Form
Liquid
Concentration
1.5 mg/mL
Amount
225 µg
Purification
Protein G
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
This antibody is specific to PAX5. It will not cross react with other PAX members.
Immunogen sequence: QPPNQPVPA SSHSIVSTGS VTQVSSVSTD SAGSSYSISG ILGITSPSAD TNKRKRDEGI QESPVPNGHS LPGRDFLRKQ MRGDLFTQQQ LEVLDRVFER QHYSDIFTTT EPIKPEQTTE YSAMASLAGG LDDMKANLAS PTPADIGSSV PGPQSYPIVT GRDLASTTLP GYPPHVPPAG QGSYSAPTLT GMVPGSEFSG SPYSHPQYSS YNDSWRFPNP GLLGSPYYYS AAARGAAPPA AATAYDRH (145-392 aa encoded by BC156927)
Target Information
PAX5 is a member of the paired box (PAX) family of transcription factors. The PAX proteins are important regulators in early development and alterations in the expression of their genes are thought to contribute to neoplastic transformation. PAX5 is the B-cell lineage specific activator protein (BSAP) that is expressed at early, but not late stages, of B-cell differentiation. Its expression has also been detected in developing CNS and testis, therefore, PAX5 may not only play an important role in B-cell differentiation, but also in neural development and spermatogenesis. Mutations in the gene can result in leukemia, acute lymphoblastic 3.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: B-cell lineage specific activator; B-cell-specific transcription factor; BSAP; BSAP; transcription factor; paired box homeotic gene 5; Paired box protein Pax-5; paired domain gene 5; Pax-5; transcription factor PAX 5
Gene Aliases: ALL3; BSAP; PAX-5; PAX5
UniProt ID: (Human) Q02548
Entrez Gene ID: (Human) 5079
RNA polymerase II core promoter proximal region sequence-specific DNA binding
RNA polymerase II transcription factor activity, sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
DNA binding
transcription factor activity, sequence-specific DNA binding
protein binding
negative regulation of transcription from RNA polymerase II promoter
regulation of transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
transcription from RNA polymerase II promoter
spermatogenesis
nervous system development
sensory organ development
lateral ventricle development
cerebral cortex development
cell differentiation
B cell differentiation
adult behavior
skeletal muscle cell differentiation
positive regulation of transcription from RNA polymerase II promoter
embryonic cranial skeleton morphogenesis
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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