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Proteintech

SFRP2 Monoclonal Antibody (1F3A1)

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View all (19) SFRP2 antibodies

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SFRP2 Monoclonal Antibody (1F3A1)

Product Details

66328-1-IG

Applications
Tested Dilution
Publications

Western Blot (WB)

1:1,000-1:4,000
View 1 publication 1 publication

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:500
-

Immunocytochemistry (ICC/IF)

1:50-1:500
-
Product Specifications

Species Reactivity

Human, Rat

Host/Isotype

Mouse / IgG1

Class

Monoclonal

Type

Antibody

Clone

1F3A1

Immunogen

SFRP2 Fusion Protein Ag18840 (1-295 aa encoded by BC008666)
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Amount

150 µg

Purification

Protein G

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: MLQGPGSLL LLFLASHCCL GSARGLFLFG QPDFSYKRSN CKPIPVNLQL CHGIEYQNMR LPNLLGHETM KEVLEQAGAW IPLVMKQCHP DTKKFLCSLF APVCLDDLDE TIQPCHSLCV QVKDRCAPVM SAFGFPWPDM LECDRFPQDN DLCIPLASSD HLLPATEEAP KVCEACKNKN DDDNDIMETL CKNDFALKIK VKEITYINRD TKIILETKSK TIYKLNGVSE RDLKKSVLWL KDSLQCTCEE MNDINAPYLV MGQKQGGELV ITSVKRWQKG QREFKRISRS IRKLQC (1-295 aa encoded by B C008666)

Target Information

This gene encodes a member of the SFRP family that contains a cysteine-rich domain homologous to the putative Wnt-binding site of Frizzled proteins. SFRPs act as soluble modulators of Wnt signaling. Methylation of this gene is a potential marker for the presence of colorectal cancer.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Bioinformatics

Protein Aliases: FRP 2; FRP-2; MGC128911; MGC153618; MGC53344; SARP 1; SARP-1; SDF 5; secreted apoptosis related protein 1; Secreted apoptosis-related protein 1; Secreted frizzled-related protein 2; sFRP 2; sFRP-2; Sfrp2 protein; similar to frizzled-like receptor CRD; testicular tissue protein Li 170; unnamed protein product

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Gene Aliases: FKSG12; FRP-2; FRP2; SARP1; SDF-5; SFRP2; UNQ361/PRO697

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UniProt ID: (Human) Q96HF1

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Entrez Gene ID: (Human) 6423, (Rat) 310552

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Function(s)
fibronectin binding integrin binding enzyme activator activity Wnt-protein binding receptor agonist activity endopeptidase activator activity molecular_function G-protein coupled receptor activity Wnt-activated receptor activity transmembrane signal receptor
Process(es)
regulation of cell growth patterning of blood vessels somitogenesis neural tube closure chondrocyte development outflow tract morphogenesis cardiac left ventricle morphogenesis apoptotic process cell-cell signaling mesodermal cell fate specification response to nutrient positive regulation of cell proliferation negative regulation of cell proliferation male gonad development response to xenobiotic stimulus anterior/posterior pattern specification negative regulation of gene expression cardiac muscle cell apoptotic process negative regulation of cardiac muscle cell apoptotic process negative regulation of epithelial to mesenchymal transition regulation of neuron projection development Wnt signaling pathway neural tube development regulation of Wnt signaling pathway cell differentiation negative regulation of Wnt signaling pathway collagen fibril organization positive regulation of cell growth negative regulation of cell growth negative regulation of cell migration BMP signaling pathway negative regulation of BMP signaling pathway positive regulation of cell adhesion mediated by integrin non-canonical Wnt signaling pathway post-anal tail morphogenesis regulation of cell proliferation negative regulation of mesodermal cell fate specification embryonic digit morphogenesis regulation of apoptotic process positive regulation of apoptotic process positive regulation of fat cell differentiation positive regulation of osteoblast differentiation positive regulation of angiogenesis negative regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter development of primary male sexual characteristics digestive tract morphogenesis stem cell fate specification negative regulation of epithelial cell proliferation negative regulation of peptidyl-tyrosine phosphorylation cartilage development convergent extension involved in axis elongation canonical Wnt signaling pathway sclerotome development negative regulation of dermatome development hematopoietic stem cell proliferation cellular response to X-ray negative regulation of canonical Wnt signaling pathway regulation of establishment of planar polarity Wnt signaling pathway involved in somitogenesis positive regulation of canonical Wnt signaling pathway negative regulation of extrinsic apoptotic signaling pathway via death domain receptors negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage regulation of midbrain dopaminergic neuron differentiation regulation of stem cell division signal transduction positive regulation of endopeptidase activity cellular response to extracellular stimulus positive regulation of peptidyl-serine phosphorylation positive regulation of catenin import into nucleus response to drug negative regulation of cysteine-type endopeptidase activity involved in apoptotic process negative regulation of JUN kinase activity bone morphogenesis planar cell polarity pathway involved in neural tube closure negative regulation of planar cell polarity pathway involved in axis elongation positive regulation of receptor activity
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