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Proteintech
CD24 Monoclonal Antibody (1H5C4)
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Product Details
67627-1-IG
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
1H5C4
Immunogen
CD24 Fusion Protein Ag11679
Conjugate
Form
Liquid
Concentration
1000 µg/mL
Purification
Protein G
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice
Product Specific Information
Aliquoting is unnecessary for -20°C storage.
Target Information
CD24 is a 35-50 kDa glycosylphosphatidylinositol (GPI)-anchored glycoprotein expressed on a variety of cell types, including erythrocytes, thymocytes, peripheral lymphocytes, and cells of the myeloid lineage. It is variably glycosylated, resulting in heterogeneity in molecular mass across different cell lineages, which can affect antibody staining levels on lymphocyte populations. In the context of B-cell development, CD24 is expressed from the pro-B-cell stage in the bone marrow through to mature, surface Ig-positive B cells, with very low or negative expression on plasma cells. It is also present on the majority of B-lineage acute lymphoblastic leukemias, B-cell chronic lymphocytic leukemias (CCLs), and B-cell non-Hodgkin's lymphomas. CD24 is thought to play a role in regulating B-cell proliferation and maturation, as well as in controlling autoimmunity. Additionally, CD24 has been reported to interact with P-selectin (CD62P), indicating a potential role in cell adhesion and signaling. CD24 is a valuable marker for studying B-cell development, leukemia, lymphoma, and autoimmune regulation, as well as its interactions with other molecules like P-selectin.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CD24; CD24 antigen (small cell lung carcinoma cluster 4 antigen); FLJ22950; FLJ43543; MGC75043; Signal transducer CD24; Small cell lung carcinoma cluster 4 antigen
Gene Aliases: CD24; CD24A
UniProt ID: (Human) P25063
Entrez Gene ID: (Human) 100133941
response to hypoxia
cell activation
regulation of cytokine-mediated signaling pathway
response to molecule of bacterial origin
immune response-regulating cell surface receptor signaling pathway
cell adhesion
positive regulation of cytosolic calcium ion concentration
Wnt signaling pathway
cell migration
regulation of cell-cell adhesion
regulation of epithelial cell differentiation
T cell costimulation
B cell receptor transport into membrane raft
chemokine receptor transport out of membrane raft
negative regulation of transforming growth factor beta3 production
positive regulation of activated T cell proliferation
cholesterol homeostasis
regulation of MAPK cascade
response to estrogen
respiratory burst
glomerular visceral epithelial cell differentiation
glomerular parietal epithelial cell differentiation
intrinsic apoptotic signaling pathway
cell-cell adhesion
positive regulation of nephron tubule epithelial cell differentiation
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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