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Antibodies Inc
GluN2C/NR2C Monoclonal Antibody (N422/18)
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Product Details
75-411
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
N422/18
Immunogen
Fusion protein amino acids 836-1233 (cytoplasmic C-terminus) of rat GluN2C (accession number Q00961) produced recombinantly in E. Coli.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Protein A
Storage buffer
TBS, pH 7.4
Contains
0.065% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Dry ice (international)
Product Specific Information
For maximum recovery of product, centrifuge the vial prior to removing the cap.
Target Information
The NMDA Receptor (NMDAR) plays an essential role in memory, neuronal development and it has also been implicated in several disorders of the central nervous system including Alzheimers, epilepsy and ischemic neuronal cell death. The NMDA receptor is also one of the principal molecular targets for alcohol in the CNS. The NMDAR is also potentiated by protein phosphorylation. The NR1 protein can form NMDA activated channels when expressed in Xenopus oocytes but the currents in such channels are much smaller than those seen in situ. Channels with more physiological characteristics are produced when the NR1 subunit is combined with one or more of th NMDAR2 (NR2 A-D) subunits.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: GluN2C; GluN2C(alt_5'UTR_77nt); GluN2C(alt_5'UTR_87nt); GluN2C(del_e2); GluN2C-b alternative isoform; GluRepsilon3; Glutamate [NMDA] receptor subunit epsilon-3; glutamate receptor; Glutamate receptor ionotropic, NMDA 2C; glutamate receptor, ionotropic, N-methyl D-aspartate 2C; glutamate receptor, ionotropic, NMDA2C; N-methyl D-aspartate receptor subtype 2C; N-methyl-D-aspartate receptor subunit 2C; NMDA glutamate receptor; NMDAR2C; NR2; putative NMDtranscript(altAcc_e11); putative NMDtranscript(altDon_e4); putative NMDtranscript(del_e4)
Gene Aliases: GluN2C; GRIN2C; NMDAR2C; NR2C
UniProt ID: (Human) Q14957, (Mouse) Q01098, (Rat) Q00961
Entrez Gene ID: (Human) 2905, (Mouse) 14813, (Rat) 24411
NMDA glutamate receptor activity
ion channel activity
cation channel activity
protein binding
ligand-gated ion channel activity
signaling receptor activity
transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential
receptor activity
ionotropic glutamate receptor activity
extracellular-glutamate-gated ion channel activity
PDZ domain binding
protein N-terminus binding
transmembrane signal receptor
ion transport
glutamate receptor signaling pathway
brain development
response to wounding
directional locomotion
ion transmembrane transport
ionotropic glutamate receptor signaling pathway
synaptic transmission, glutamatergic
negative regulation of protein catabolic process
regulation of membrane potential
regulation of synaptic plasticity
regulation of neuronal synaptic plasticity
neuromuscular process controlling balance
positive regulation of synaptic transmission, glutamatergic
excitatory postsynaptic potential
long-term synaptic potentiation
calcium ion transmembrane import into cytosol
cation transmembrane transport
excitatory chemical synaptic transmission
protein localization to postsynaptic membrane
regulation of cation transmembrane transport
positive regulation of excitatory postsynaptic potential
startle response
transport
protein localization
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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