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Antibodies Inc
Slc18a2/VMAT2 Monoclonal Antibody (N449/73), FL490
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Product Details
75-436-FL490
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Mouse
/ IgG2b
Class
Monoclonal
Type
Antibody
Clone
N449/73
Immunogen
Fusion protein amino acids 42-132 (first lumenal domain) of mouse Slc18a2 (accession number Q66L40) produced recombinantly in E. Coli.
Conjugate
Excitation/Emission Max
491/515 nm
Form
Liquid
Concentration
0.5 mg/mL
Amount
100 µg
Purification
Protein A
Storage buffer
PBS
Contains
0.09% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Dry ice (international)
Product Specific Information
For maximum recovery of product, centrifuge the vial prior to removing the cap.
Target Information
VMAT2 is involved in the ATP-dependent vesicular transport of biogenic amine neurotransmitters. pumps cytosolic monoamines including dopamine, norepinephrine, serotonin, and histamine into synaptic vesicles. It is a requisite for vesicular amine storage prior to secretion via exocytosis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: MGC120477; MGC120478; MGC26538; monoamine neurotransmitter transporter; Monoamine transporter; solute carrier family 18 (vesicular monoamine transporter), member 2; solute carrier family 18 (vesicular monoamine), member 2; Solute carrier family 18 A2 (vesicular monoamine transporter 2); Solute carrier family 18 member 2; solute carrier family 18, member 2; synaptic vesicle amine transporter, brain; synaptic vesicle monoamine transporter, brain; Synaptic vesicular amine transporter; unnamed protein product; VAT2; vesicle monoamine transporter type 2; vesicle monoamine/H+ antiporter; Vesicular amine transporter 2; Vesicular monoamine transporter 2
Gene Aliases: 1110037L13Rik; 9330105E13; MNAT; PKDYS2; SLC18A2; SVAT; SVMT; VAT2; VMAT-2; VMAT2
UniProt ID: (Human) Q05940, (Mouse) Q8BRU6, (Rat) Q01827
Entrez Gene ID: (Human) 6571, (Mouse) 214084, (Rat) 25549
serotonin:sodium symporter activity
protein binding
monoamine transmembrane transporter activity
monoamine:proton antiporter activity
transmembrane transporter activity
amine transmembrane transporter activity
drug binding
serotonin transmembrane transporter activity
drug transmembrane transporter activity
enzyme binding
heat shock protein binding
secondary carrier transporter
response to amphetamine
serotonin secretion by mast cell
histamine secretion by mast cell
neurotransmitter transport
serotonin transport
chemical synaptic transmission
locomotory behavior
response to toxic substance
post-embryonic development
aminergic neurotransmitter loading into synaptic vesicle
monoamine transport
dopamine transport
serotonin uptake
histamine uptake
establishment of localization in cell
transmembrane transport
neurotransmitter loading into synaptic vesicle
somato-dendritic dopamine secretion
hydrogen ion transmembrane transport
negative regulation of reactive oxygen species biosynthetic process
transport
aging
organic cation transport
drug transport
obsolete death
insulin secretion
cellular response to drug
glucose homeostasis
negative regulation of neurotransmitter transport
ammonium transmembrane transport
drug transmembrane transport
response to herbicide
response to metal ion
response to zinc ion
endocytic recycling
response to cocaine
response to drug
response to starvation
response to corticosterone
cellular response to ammonium ion
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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