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Proteintech
LAT Recombinant Rabbit Monoclonal Antibody (2P13)
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Product Details
82901-1-RR
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Expression System
CHO cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
2P13
Immunogen
Peptide
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Protein A
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice
Target Information
LAT (Linker for Activation of T cells) is a 36-38 kDa double-palmitoylated transmembrane adaptor protein expressed by T cells, pre-B cells, NK cells, mast cells and platelets. After immunoreceptor triggering, LAT becomes multiply tyrosine-phosphorylated by Syk-, Src-, or Tec-family kinases, providing docking sites for downstream signaling molecules. LAT is essential for TCR-dependent T cell- and FcepsilonRI-dependent mast cell activation, as well as for maturation of early thymocytes. It is also involved in NK cell signaling and platelet activation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 36 kDa phospho-tyrosine adapter protein; 36 kDa phospho-tyrosine adaptor protein; 36 kDa phosphotyrosine adapter protein; linker for activation of T cells, transmembrane adaptor; Linker for activation of T-cells family member 1; linker protein; p36-38; pp36; tyrosine kinase substrate
Gene Aliases: IMD52; LAT; LAT1; pp36
UniProt ID: (Human) O43561, (Mouse) O54957
Entrez Gene ID: (Human) 27040, (Mouse) 16797
adaptive immune response
lymphocyte homeostasis
immune system process
inflammatory response
immune response
signal transduction
integrin-mediated signaling pathway
Ras protein signal transduction
gene expression
calcium-mediated signaling
membrane raft distribution
intracellular signal transduction
T cell activation
mast cell degranulation
positive regulation of MAPK cascade
positive regulation of protein kinase activity
homeostasis of number of cells
T cell receptor signaling pathway
regulation of T cell activation
cellular defense response
transmembrane receptor protein tyrosine kinase signaling pathway
positive regulation of signal transduction
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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