|Immunocytochemistry (ICC)||5 ug/mL|
|Immunofluorescence (IF)||5 ug/mL|
|Western Blot (WB)||1 - 2 ug/mL|
|Tested Species reactivity||Human|
|Host / Isotype||Rabbit / IgG|
|Immunogen||An 18 amino acid synthetic peptide near the amino terminus of human ABCA7|
|Purification||Antigen affinity chromatography|
|Contains||0.02% sodium azide|
|Storage conditions||Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C|
A suggested positive control is 293 cell lysate.
PA5-34396 can be used with blocking peptide PEP-1438.
ATP-binding cassette (ABC) transporters are an evolutionarily conserved family that use ATP hydrolysis to catalyze the transport of various molecules across cell membranes. They are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). ABCA7, a member of the ABC1 subfamily, is a full-size ABC transporter consisting of two sets of the multiple membrane-spanning domains plus the Walker motifs for the ATP interaction. ABCA7 shows the highest homology to ABCA1, an essential molecule for cholesterol homeostasis. The high expression levels of ABCA7 in peripheral leukocytes, thymus, spleen and bone marrow suggests a role in the immune system lipid homeostasis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: ABC Transporter 1; ABC1; ABCA-SSN; ABCA7; ATP-binding Cassette 1; ATP-binding Cassette Sub-family A ABC1 member 7; ATP-binding cassette sub-family A member 7; ATP-binding Cassette Transporter 1; ATP-binding cassette, sub-family A (ABC1), member 7; Autoantigen SS-N; CERP; Macrophage ABC transporter
Gene Aliases: ABCA-SSN; ABCA7; ABCX; AD9
UniProt ID: (Human) Q8IZY2
Entrez Gene ID: (Human) 10347
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