|Tested species reactivity||Human|
|Published species reactivity||Human|
|Host / Isotype||Rabbit / IgG|
|Immunogen||KLH conjugated synthetic peptide between 767-793 amino acids from the central region of human ABCC10|
|Purification||Antigen affinity chromatography|
|Contains||0.09% sodium azide|
|Storage Conditions||Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
|Tested Applications||Dilution *|
|Flow Cytometry (Flow)||1:10-1:50|
|Western Blot (WB)||1:1000|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
|Western Blot (WB)||See 2 publications below|
The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, and White). This ABC full-transporter is a member of the MRP subfamily which is involved in multi-drug resistance. Multiple transcript variants encoding different isoforms have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
The small molecule tyrosine kinase inhibitor NVP-BHG712 antagonizes ABCC10-mediated paclitaxel resistance: a preclinical and pharmacokinetic study.
PA5-23652 was used in western blot to study the role of ABC transporter subfamily C member 10 plays in paclitaxel-induced resistance to chemotherapy
|Kathawala RJ,Wei L,Anreddy N,Chen K,Patel A,Alqahtani S,Zhang YK,Wang YJ,Sodani K,Kaddoumi A,Ashby CR,Chen ZS||Oncotarget (6:510)||2015|
Linsitinib (OSI-906) antagonizes ATP-binding cassette subfamily G member 2 and subfamily C member 10-mediated drug resistance.
PA5-23652 was used in western blot to study the ability of linsitinib to attenuate drug resistance mediated by the ABC-G2 and ABC-C10 transporters via direct reporter antagonism
|Zhang H,Kathawala RJ,Wang YJ,Zhang YK,Patel A,Shukla S,Robey RW,Talele TT,Ashby CR,Ambudkar SV,Bates SE,Fu LW,Chen ZS||The international journal of biochemistry and cell biology (51:111)||2014|