|Immunohistochemistry (Paraffin) (IHC (P))||1:100-1:400|
|In vitro Assay (IV)||Assay-Dependent|
|Western Blot (WB)||1:500|
|Tested Species reactivity||Hamster, Human, Mouse, Rabbit, Rat|
|Host / Isotype||Rabbit / IgG|
|Immunogen||A synthetic peptide made to an internal region of human ABCG1 (between residues 300-400).|
|Purification||Antigen affinity chromatography|
|Storage buffer||tris citrate, pH 7-8|
|Contains||0.1% sodium azide|
|Storage conditions||4° C, do not freeze|
The target sequence has 88% sequence homology with rat.
ATP-binding cassette (ABC) transporter genes are involved in the regulation of the amount of dietary cholesterol retained in the body. The ABC transporter ABCG1 (ABC8) is expressed on the cell surface and in intracellular compartments of cholesterol-laden macrophages and is induced in monocyte-derived macrophages during cholesterol influx mediated by acetylated low-density lipoprotein. In contrast, lipid efflux in cholesterol-laden macrophages, mediated by the cholesterol acceptor HDL, suppresses the expression of ABCG1.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: ABC transporter 8; ATP-binding cassette 8; ATP-binding cassette sub-family G member 1; ATP-binding cassette transporter 8; ATP-binding cassette transporter member 1 of subfamily G; ATP-binding cassette, subfamily G, member 1; homolog of Drosophila white; MGC34313; white protein homolog; white protein homolog (ATP-binding cassette transporter 8); WHITE1
Gene Aliases: ABC8; AW413978; White; WHITE1
Molecular Function: Transporter
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