This target displays homology in the following species: Cow: 85%; Dog: 93%; Guinea Pig: 86%; Horse: 85%; Human: 100%; Mouse: 86%; Rabbit: 93%; Rat: 90%; Zebrafish: 85%
This gene encodes a mitochondrial acyl-coenzyme A synthetase that is specific for medium chain fatty acids. These enzymes catalyze fatty acid activation, the first step of fatty acid metabolism, through the transfer of acyl-CoA. These enzymes also participate in the glycine conjugation pathway in the detoxification of xenobiotics such as benzoate and ibuprofen. Expression levels of this gene in the kidney may be correlated with kidney function. This gene and its paralog ACSM2B (Gene ID: 348158), both present on chromosome 16, likely arose from a chromosomal duplication event.
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Protein Aliases: acyl-CoA synthetase medium-chain family member 2; Acyl-CoA synthetase medium-chain family member 2A; Acyl-coenzyme A synthetase ACSM2A, mitochondrial; Benzoate--CoA ligase; Butyrate--CoA ligase 2A; Butyryl-coenzyme A synthetase 2A; Homolog of rat kidney-specific (KS); Middle-chain acyl-CoA synthetase 2A
Gene Aliases: A-923A4.1; ACSM2; ACSM2A; MACS2
UniProt ID: (Human) Q08AH3
Entrez Gene ID: (Human) 123876