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AKAP5 Polyclonal Antibody

View all (6) AKAP5 antibodies

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Product Details

BS-6980R

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:2,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:200
-

Immunohistochemistry (Frozen) (IHC (F))

1:100-1:500
-

Immunocytochemistry (ICC/IF)

1:50-1:200
-

ELISA (ELISA)

1:500-1:1,000
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

KLH conjugated synthetic peptide derived from human AKAP5, amino acids 611-714.

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Amount

100 µg

Purification

Protein A

Storage buffer

0.01M TBS, pH 7.4, with 1% BSA, 50% glycerol

Contains

0.02% ProClin 300

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

Target Information

AKAPs (A-kinase anchoring proteins), as their name implies, are a family of scaffolding proteins that bind regulatory subunits of Protein Kinase A (PKA) thus localizing PKA activity to distinct regions of the cell. Beyond a common amphipathic alpha helix that is responsible for recruiting the PKA regulatory subunit (RI alpha, RII alpha, RI beta, or RII beta), individual AKAPs contain additional domains responsible for the recrutiment of additional signaling proteins (phosphodiesterases, phosphatases, cytoskeletal components, other kinase, etc.) or restricting AKAP to a specific subcellular location. AKAP5 (also known as P75, AKAP75, or AKAP79) is predominantly expressed in neuronal tissues and cells where it serves to localize type II PKA to post-synaptic densities. AKAP5 specifically binds to the regulatory subunit of PKAII beta, anchoring the enzyme to the plasma membrane and sites of cytoskeletal/membrane junctions. The other binding domains of AKAP5 have been shown to interact with calmodulin, PP2B, and calcineurin suggesting that AKAP5 may act to coordinate the cAMP- and Ca2+-sensing pathways in various cell types.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: A kinase (PRKA) anchor protein 5; A-kinase anchor protein 150 kDa; A-kinase anchor protein 5; A-kinase anchor protein 79 kDa; A-kinase anchoring protein 75/79; AKAP 150; AKAP 5; AKAP 79; AKAP-5; cAMP-dependent protein kinase regulatory subunit II high affinity-binding protein; H21; RII-B-binding protein; unnamed protein product

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Gene Aliases: 3526401B18Rik; AKAP 150; AKAP-5; AKAP150; AKAP5; AKAP75; AKAP79; BB098886; Gm258; H21; P150

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UniProt ID: (Human) P24588, (Mouse) D3YVF0

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Entrez Gene ID: (Human) 9495, (Mouse) 238276, (Rat) 171026

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Function(s)
protein binding calmodulin binding adenylate cyclase binding SH3 domain binding protein phosphatase 2B binding beta-2 adrenergic receptor binding protein kinase A regulatory subunit binding glutamate receptor binding GABA receptor binding protein kinase A binding binding, bridging scaffold protein binding G-protein coupled receptor binding actin binding kinase binding protein kinase binding protein domain specific binding protein complex binding cadherin binding scaffold/adaptor protein
Process(es)
signal transduction adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway negative regulation of adenylate cyclase activity chemical synaptic transmission regulation of protein kinase A signaling calcineurin-NFAT signaling cascade positive regulation of calcineurin-NFAT signaling cascade positive regulation of long-term synaptic potentiation positive regulation of protein localization to plasma membrane positive regulation of calcium ion import across plasma membrane positive regulation of endosome to plasma membrane protein transport positive regulation of protein phosphorylation protein targeting positive regulation of calcium ion transport into cytosol positive regulation of protein kinase A signaling positive regulation of cAMP biosynthetic process amylase secretion negative regulation of potassium ion transport negative regulation of ion transport cellular protein complex disassembly positive regulation of adenylate cyclase activity positive regulation of dendrite morphogenesis positive regulation of NFAT protein import into nucleus response to muscle activity spinal cord development hippocampus development response to electrical stimulus maternal process involved in female pregnancy cellular response to organonitrogen compound
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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