Immunogen sequence: WAAPVKSQAI AQPATTAKSH LHQKPGQTWK NKEHHLSDRE FVFKEPQQVV RRAPEPRVID REGVYEISLS PTGVSRVCLY PGFVDVKEAD WILEQLCQDV PWKQRTGIRE DITYQQPRLT AWYGEL
Highest antigen sequence identity to the following orthologs: Mouse - 78%, Rat - 79%.
Dioxygenase that repairs alkylated DNA containing 1- methyladenine (1meA) and 3-methylcytosine (3meC) by oxidative demethylation. Has a strong preference for single-stranded DNA. Able to process alkylated 3mC within double-stranded regions via its interaction with ASCC3, which promotes DNA unwinding to generate single-stranded substrate needed for ALKHB3. May also act on RNA. Requires molecular oxygen, alpha-ketoglutarate and iron.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: 11411-; ABH3; alkB homolog 3, alpha-ketoglutarate-dependent dioxygenase; alkB, alkylation repair homolog 3; ALKBH3; Alkylated DNA repair protein alkB homolog 3; Alpha-ketoglutarate-dependent dioxygenase alkB homolog 3; DEPC-1; DEPC1; hABH3; Prostate cancer antigen 1; prostate cancer antigen-1
Gene Aliases: ABH3; ALKBH3; DEPC-1; DEPC1; hABH3; PCA1
UniProt ID: (Human) Q96Q83
Entrez Gene ID: (Human) 221120