This gene encodes a multi-domain protein that is predominantly expressed in brain and testis. This protein interacts with amyloid beta protein precursor (AbetaPP) and may have a role in normal brain development, and in the pathogenesis of Alzheimer's disease. Expression of this gene has been shown to be elevated in patients with pre-B cell acute lymphocytic leukemia associated with t(1;19) translocation. Alternatively spliced transcript variants encoding different isoforms (some with different subcellular localization) have been described for this gene.
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Protein Aliases: AIDA; AIDA 1; AIDA-1; amyloid-beta precursor protein intracellular domain associated protein 1; Amyloid-beta protein intracellular domain-associated protein 1; ANKS1B; ANKS2; Ankyrin repeat and sterile alpha motif domain-containing protein 1B; cajalin 2; E2A PBX1 associated protein; E2A-PBX1-associated protein; EB 1; EB-1
Gene Aliases: AIDA; AIDA-1; AIDA-1b; ANKS1B; ANKS2; C030032C09Rik; cajalin-2; E530015N03Rik; EB-1; EB1; ENSMUSG00000078431; Gm10937; Gm1555
Molecular Function: transmembrane receptor regulatory/adaptor protein